| Prevalence of gallstones in patients with chronic myelocytic leukemia. | |
| | |
MedLine Citation:
|
PMID: 19349718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The aim of the present case-control study was to determine whether or not the prevalence of gallbladder stones (GBS) was increased in patients with chronic myelocytic leukemia (CML) and to investigate clinical and laboratory characteristics of CML patients with GBS. SUBJECTS AND METHODS: This study included 56 patients with CML and 55 sex- and age-matched healthy controls. All participants underwent abdominal ultrasonography and the main clinical and laboratory characteristics were recorded. RESULTS: Gallbladder stones were detected in 13 (23.6%) patients with CML and in 3 (5.4%) control individuals (p < 0.05). The mean follow-up period of CML patients after diagnosis was 54.6 months, range 3-120 months. Hemoglobin levels were higher in the control group than in CML patients. However, total bilirubin, unconjugated bilirubin, lactate dehydrogenase levels, leukocyte and thrombocyte counts, frequency of splenomegaly and hepatomegaly were higher in the CML than in the control group (p < 0.05). Other clinical and laboratory values were not significantly different between the groups. CML patients with and without GBS were also compared for clinical and laboratory values. Age and follow-up period of CML patients after diagnosis were higher in the CML patients with GBS (p < 0.05). CONCLUSIONS: Higher prevalence of GBS in CML patients than in healthy controls was detected. We suggest that CML may increase the frequency of GBS, apart from other well-known risk factors. This risk is probably related to increased unconjugated bilirubin, which determines hemolysis, older age and long follow-up period of CML patients after diagnosis. |
| | |
Authors:
|
Fehmi Ates; Mehmet Ali Erkurt; Melih Karincaoglu; Murat Aladag; Ismet Aydogdu |
Related Documents
:
|
11597728 - Re-evaluation of refractory anemia with excess blasts in transformation. 2931098 - Lineage specific classification of leukaemia: results of the analysis of sixty cases of... 11403708 - Microsatellite instability in acute myelocytic leukaemia developed from a-bomb survivors. 12767088 - Results of imatinib mesylate therapy in patients with refractory or recurrent acute mye... 8623638 - Distribution of serouslike bone marrow changes in the lower limbs of patients with anor... 7985828 - Plasma levels of tumor necrosis factor and endothelial response in patients with chroni... |
Publication Detail:
|
Type: Journal Article Date: 2009-04-06 |
Journal Detail:
|
Title: Medical principles and practice : international journal of the Kuwait University, Health Science Centre Volume: 18 ISSN: 1423-0151 ISO Abbreviation: Med Princ Pract Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-04-07 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8901334 Medline TA: Med Princ Pract Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 175-9 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 S. Karger AG, Basel. |
Affiliation:
|
Department of Gastroenterology, Inonu University School of Medicine, Malatya, Turkey. drfehmiates@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Analysis of Variance Case-Control Studies Female Gallstones / blood, complications*, epidemiology*, ultrasonography Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications* Liver Function Tests Male Middle Aged Prevalence Risk Factors Turkey / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pattern of upper respiratory tract infections and physicians' antibiotic prescribing practices in Ba...
Next Document: Decreased nucleoside transport and hENT1 transporter expression in beta-thalassemia major.