| Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis. | |
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MedLine Citation:
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PMID: 19279015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc). METHODS: The EUSTAR database was first searched. A case-control study of a patient subset was then performed to further identify independent factors associated with LV dysfunction by simple and multiple regression. RESULTS: Of 7073 patients, 383 (5.4%) had an LV ejection fraction (EF) of <55%. By multiple regression analysis, age, sex, diffuse cutaneous disease, disease duration, digital ulcerations, renal and muscle involvement, disease activity score, pulmonary fibrosis and pulmonary arterial hypertension were associated with LV dysfunction. In the second phase, 129 patients with SSc with LVEF <55% were compared with 256 patients with SSc with normal LVEF. Male sex (OR 3.48; 95% CI 1.74 to 6.98), age (OR 1.03; 95% CI 1.01 to 1.06), digital ulcerations (OR 1.91; 95% CI 1.05 to 3.50), myositis (OR 2.88; 95% CI 1.15 to 7.19) and use of calcium channel blockers (OR 0.41; 95% CI 0.22 to 0.74) were independent factors associated with LV dysfunction. CONCLUSION: The prevalence of LV dysfunction in SSc is 5.4%. Age, male gender, digital ulcerations, myositis and lung involvement are independently associated with an increased prevalence of LV dysfunction. Conversely, the use of calcium channel blockers may be protective. |
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Authors:
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Y Allanore; C Meune; M C Vonk; P Airo; E Hachulla; P Caramaschi; G Riemekasten; F Cozzi; L Beretta; C T Derk; A Komócsi; D Farge; A Balbir; V Riccieri; O Distler; A Chialà; N Del Papa; K Pasalic Simic; M Ghio; B Stamenkovic; S Rednic; N Host; R Pellerito; E Zegers; A Kahan; U A Walker; M Matucci-Cerinic; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 69 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 218-21 Citation Subset: IM |
Affiliation:
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Service de Rhumatologie A, Hôpital Cochin, Université Paris Descartes, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France. yannick.allanore@cch.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Calcium Channel Blockers / therapeutic use Epidemiologic Methods Europe / epidemiology Female Fingers Humans Male Middle Aged Myositis / complications, epidemiology Scleroderma, Systemic / complications*, epidemiology Sex Factors Skin Ulcer / complications, epidemiology Stroke Volume Ventricular Dysfunction, Left / epidemiology, etiology*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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