| Prevalence of extended-spectrum beta-lactamase-producing Enterobacter cloacae in the Asia-Pacific region: results from the SENTRY Antimicrobial Surveillance Program, 1998 to 2001. | |
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MedLine Citation:
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PMID: 14638518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Enterobacter cloacae strains from hospitalized patients with a range of infections were collected by 17 laboratories in the Asia-Pacific region and South Africa. Isolates for which ceftriaxone MICs were above 1 microg/ml and/or ceftazidime MICs were above 2 microg/ml, as well as 46 strains for which ceftriaxone and/or ceftazidime MICs were at or below these values, were screened for levels of extended-spectrum beta-lactamase (ESBL) production through the use of broth microdilution for the detection of clavulanate enhancement of the activity of ceftriaxone, ceftazidime, and cefepime. Of the isolates examined, ceftriaxone and/or ceftazidime had elevated MICs for 44%, of which 36% were ESBL positive. ESBL-positive strains were commonly susceptible to piperacillin-tazobactam and more frequently resistant to several other antimicrobials studied. A cefepime MIC above 0.25 microg/ml had the highest sensitivity (100%) and specificity (74%) for predicting the presence of an ESBL. |
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Authors:
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J M Bell; J D Turnidge; R N Jones; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 47 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2004-01-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 3989-93 Citation Subset: IM |
Affiliation:
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Microbiology and Infectious Diseases Department, Women's and Children's Hospital, Adelaide, Australia. bellj@mail.wch.sa.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asia
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epidemiology Cephalosporins / pharmacology Clavulanic Acid / pharmacology Cross Infection / epidemiology, microbiology Enterobacter cloacae / drug effects*, enzymology* Enterobacteriaceae Infections / epidemiology*, microbiology Enzyme Inhibitors / pharmacology Humans Microbial Sensitivity Tests Pacific Islands / epidemiology Penicillins / pharmacology Phenotype South Africa / epidemiology beta-Lactamases / antagonists & inhibitors, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 0/Enzyme Inhibitors; 0/Penicillins; 58001-44-8/Clavulanic Acid; EC 3.5.2.6/beta-Lactamases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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