| Prevalence and effect of hemoglobin E disorders on Hba1c and lipid profile of diabetic patients at Surin Hospital. | |
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MedLine Citation:
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PMID: 21425726 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the prevalence of hemoglobin E disorders (HbE) and their characteristics in diabetic patients at Surin Hospital. Effects of HbE on HbA1c measurement and other variables in diabetic patients were also studied. MATERIAL AND METHOD: A cross-sectional study was performed. One thousand nine hundred seventy eight patients were recruited randomly using a systemic random sampling method HbE screening test and Hb typing was performed HbA lc was measured by turbidimetric inhibition immunoassay. RESULTS: The prevalence of homozygous HbE (HbEE) and HbE trait were 7.9% and 35.3% respectively. When compared with the negative screening group, the variables that were significantly higher in the HbEE group were hemoglobin A1c (HbA1c) < 6.5% (p < 0.010), HbA1c < 7% (p < 0.010), serum cholesterol level (CHOL) < 200 mg/dl (p < 0.010), low density lipoprotein (LDL) < 100 mg/dl (p = 0.021), and anemia by Hb measurement (p < 0.010). The adjusted odds ratio and 95% confidence interval (CI) of HbA1c < 6.5% and < 7% in HbEE when compared with the negative screening group were 5.16 (3.55-7.50) and 4.60 (3.04-6.97) respectively The means of HbA1c, Hb, CHOL, and LDL in HbEE were significantly lower than the other groups (p < 0.010 in all variables). The adjusted odds ratio and 95% CI of HbA1c < 6.5% and < 7% in HbE trait when compared with the negative screening group were 1.12 (1.01-1.24) and 1.17 (1.06-1.29) respectively. CONCLUSION: Hemoglobin E disorders are highly prevalent in diabetes patients at Surin Hospital. HbA1c, CHOL, and LDL were significantly lower in diabetic patients with HbEE. |
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Authors:
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Wasunt Srisurin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 94 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-03-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 36-42 Citation Subset: IM |
Affiliation:
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Department of Medicine, Surin Hospital, Surin, Thailand. wasuntsrisurin@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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