| Prevalence of donor-transmitted coronary artery disease and its influence on heart transplant outcomes. | |
| | |
MedLine Citation:
|
PMID: 20970589 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: It is uncertain whether donor-transmitted coronary artery disease (DTCAD) affects heart transplant (HT) recipients. METHODS: This retrospective analysis includes records of all patients who underwent a HT at our center over an 8-year period, who survived for at least 1 month, and who were examined by coronary angiography within 2 months post-HT. We distinguished angiographically from keep ultrasonography (IVUS) detected DTCAD. Major adverse cardiovascular events (MACE) comprised death, myocardial infarction, unstable angina, coronary revascularization, and admission because of heart failure not due to an acute rejection episode. RESULTS: Among the 171 patients of mean age 53±13 years and including 83% men, 65 (38%) were evaluated by IVUS. Donors were aged 40±14 years (range=14-73). Angiographic DTCAD affected seven patients (4.1%), and IVUS-detected DTCAD, 35 (53.8% of those examined by IVUS). DTCAD donors were older than non-DTCAD donors, by an average of 13 years (P=.001) for angiographic DTCAD and 18 years (P<.0001) for IVUS-detected DTCAD. Two patients underwent percutaneous revascularization upon detection of angiographic DTCAD. The angiographic- and IVUS-detected DTCAD groups did not differ significantly from the corresponding non-DTCAD groups as regards MACE incidence during 54±41 and 38±20 months follow-up, respectively. Cox regression analysis with adjustment for relevant confounders confirmed that IVUS-detected DTCAD was not a predictor of MACE (hazard ratio 1.2, 95% confidence interval 0.2-8.1). CONCLUSIONS: Among HT patients surviving≥1 month, angiographic- and IVUS-detected DTCAD showed prevalences of <10% and >50%, respectively. Neither detection method was associated with a greater long-term incidence of MACE. |
| | |
Authors:
|
R Estevez-Loureiro; M J Paniagua-Martin; R Calviño-Santos; J M Vazquez-Rodríguez; J Salgado-Fernandez; R Marzoa-Rivas; E Barge-Caballero; Z Grille; A Pérez-Pérez; J A Rodríguez-Fernandez; N Vázquez-González; J J Cuenca-Castillo; A Castro-Beiras; M G Crespo-Leiro |
Related Documents
:
|
19804129 - Is multislice computed tomography of value for the imaging of myocardial infarction? 7708189 - Intra-arterial digital subtraction angiography with isotonic dimeric (iodixanol) and mo... 19495829 - Giant coronary aneurysm in adult kawasaki disease: angiographic, 64-slice coronary mdct... 10739729 - Differences in use of coronary angiography and outcome of myocardial infarction in toul... 11571239 - Left ventricular muscle mass and elevated heart rate are associated with coronary plaqu... 16444989 - The relationship between coronary artery calcification detected by non-gated multi-dete... 16168419 - Left ventricular shape-based contractility index. 21843109 - Rhesus monkey cardiosphere-derived cells for myocardial restoration. 9358809 - Increased risk of coronary artery bypass grafting for left ventricular dysfunction with... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
|
Languages: eng Pagination: 2987-91 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Heart Transplant and Advanced Heart Failure Unit, Division of Cardiology, Hospital Universitario A Coruña, La Coruña, Spain. Rodrigo.Estevez.Loureiro@sergas.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiovascular events after simultaneous pancreas-kidney transplantation.
Next Document: Proliferation signal inhibitors in heart transplantation: a 5-year experience.