Document Detail

Prevalence and distribution of fasciculations in healthy adults: Effect of age, caffeine consumption and exercise.
MedLine Citation:
PMID:  19533451     Owner:  NLM     Status:  MEDLINE    
Our objective was to determine the prevalence and distribution of fasciculations in healthy adults and to assess the effect of age, caffeine and exercise. Fasciculations were studied with ultrasonography in 58 healthy adults in various age categories. Questionnaires were used to determine effect of caffeine and regular exercise on the presence of fasciculations. Finally, we tested the effect of strenuous exercise on fasciculations in 10 healthy adults. Twenty-five subjects (43%) showed fasciculations on ultrasonography, mostly in the abductor hallucis longus muscle. Fasciculations were only sporadically encountered in muscle groups above the knee. Subjects with fasciculations were significantly older than those without. Caffeine and regular physical exercise did not influence the prevalence of fasciculations. However, strenuous physical exercise caused a temporary increase in fasciculations, but only in lower leg muscles. Fasciculations above the knee should raise suspicion and may warrant further investigation.
Jiske Fermont; Ilse M P Arts; Sebastiaan Overeem; Bert U Kleine; H Jurgen Schelhaas; Machiel J Zwarts
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  11     ISSN:  1471-180X     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  IM    
Neuromuscular Centre Nijmegen, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands.
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MeSH Terms
Age Distribution
Aged, 80 and over
Caffeine / administration & dosage*
Central Nervous System Stimulants / administration & dosage
Fasciculation / epidemiology*,  ultrasonography*
Middle Aged
Muscle, Skeletal / ultrasonography
Reference Values
Young Adult
Reg. No./Substance:
0/Central Nervous System Stimulants; 58-08-2/Caffeine

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