| Prevalence and determinants of human papillomavirus infection and cervical lesions in HIV-positive women in Kenya. | |
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MedLine Citation:
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PMID: 23033006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We assessed the association of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) with various characteristics, CD4 count and use of combination antiretroviral therapy (cART) among HIV-positive women. METHODS: Cross-sectional study of 498 HIV-positive women who underwent HPV PCR-based testing, cytology, and systematic cervical biopsy. RESULTS: In all, 68.7% of women were HPV-positive, 52.6% had high-risk (hr) HPV, and 40.2% multiple type infections. High-risk human papillomavirus-positivity did not vary significantly by age but it was negatively associated with education level. The most frequent types in 113 CIN2/3 were HPV16 (26.5%), HPV35 (19.5%), and HPV58 (12.4%). CD4 count was negatively associated with prevalence of hrHPV (P<0.001) and CIN2/3 among non-users of cART (P=0.013). Combination antiretroviral therapies users (≥2 year) had lower hrHPV prevalence (prevalence ratio (PR) vs non-users=0.77, 95% confidence interval (CI): 0.61-0.96) and multiple infections (PR=0.68, 95% CI: 0.53-0.88), but not fewer CIN2/3. The positive predictive value of hrHPV-positivity for CIN2/3 increased from 28.9% at age <35 years to 53.3% in ≥45 years. CONCLUSION: The burden of hrHPV and CIN2/3 was high and it was related to immunosuppression level. Combination antiretroviral therapies ( ≥2 year) use had a favourable effect on hrHPV prevalence but cART in our population may have been started too late to prevent CIN2/3. |
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Authors:
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H De Vuyst; N R Mugo; M H Chung; K P McKenzie; E Nyongesa-Malava; V Tenet; J W Njoroge; S R Sakr; Cjl M Meijer; P J F Snijders; F S Rana; S Franceschi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-02 |
Journal Detail:
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Title: British journal of cancer Volume: 107 ISSN: 1532-1827 ISO Abbreviation: Br. J. Cancer Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-24 Completed Date: 2013-03-21 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 1624-30 Citation Subset: IM |
Affiliation:
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International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, Lyon, France. devuysth@iarc.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervical Intraepithelial Neoplasia / epidemiology*, virology Cohort Studies Cross-Sectional Studies Female HIV Infections / epidemiology*, virology Humans Kenya / epidemiology Middle Aged Papillomavirus Infections / epidemiology*, virology Prevalence Uterine Cervical Neoplasms / epidemiology*, virology |
| Grant Support | |
ID/Acronym/Agency:
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5K23AI065222-04/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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