Document Detail

Prevalence and determinants of anemia in adults with complex congenital heart disease and ventricular dysfunction (subaortic right ventricle and single ventricle physiology).
MedLine Citation:
PMID:  18721525     Owner:  NLM     Status:  MEDLINE    
Anemia is well recognized as a marker of poor prognosis in patients with acquired heart disease and heart failure. Adults with complex congenital heart disease and ventricular dysfunction (subaortic right ventricle or single-ventricle physiology) represent a different population, because they are typically much younger and have less co-morbidity compared with patients with acquired forms of heart disease. The purpose of this study was to evaluate the prevalence and determinants of anemia in this population. Baseline hemoglobin levels were recorded at the time of the initial clinic visit, and final hemoglobin levels were those recorded before death or transplantation or at study completion. Anemia was defined as hemoglobin <135 g/L in men and <120 g/L in women. One hundred sixty-seven patients (100 men, mean age 34 +/- 8 years, mean ejection fraction 35 +/- 9%) were included, 66 with atrial switch operations, 42 with congenitally corrected transposition of the great arteries, and 59 with Fontan physiology. The mean hemoglobin level at baseline was 149 +/- 22 g/L and at follow-up was 139 +/- 29 g/L. The overall prevalence of anemia was 29% at completion. Hyponatremia, decreased renal function, and the use of warfarin were independent predictors of anemia. In conclusion, anemia is common in patients with complex congenital heart disease and ventricular dysfunction, in particular those with Fontan physiology.
Nicholas Collins; Sanaz Piran; Jeanine Harrison; Eduardo Azevedo; Erwin Oechslin; Candice K Silversides
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-17
Journal Detail:
Title:  The American journal of cardiology     Volume:  102     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  AIM; IM    
Toronto Congenital Cardiac Centre for Adults, University Health Network, Toronto General Hospital, Division of Cardiology, University of Toronto, Toronto, Canada.
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MeSH Terms
Anemia / blood,  epidemiology*,  etiology
Disease Progression
Heart Defects, Congenital / complications*,  diagnosis,  physiopathology
Heart Ventricles / abnormalities*
Hemoglobins / metabolism*
Magnetic Resonance Imaging
Radionuclide Ventriculography
Retrospective Studies
Severity of Illness Index
Ventricular Dysfunction / complications*,  diagnosis,  physiopathology
Reg. No./Substance:

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