Document Detail

Prevalence and correlates of prolonged fatigue in a U.S. sample of adolescents.
MedLine Citation:
PMID:  23632835     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Prolonged fatigue in adolescents has a major impact on social functioning and school attendance. In adults, prolonged fatigue substantially overlaps with mood and anxiety disorders. Extending the data to adolescents, the authors studied the prevalence and correlates of fatigue in a representative U.S. sample.
METHOD: The participants were 10,123 adolescents ages 13-18 years from the National Comorbidity Survey Adolescent Supplement. They were interviewed about prolonged fatigue, defined as extreme fatigue with at least one associated symptom (pains, dizziness, headache, sleep disturbance, inability to relax, irritability) that does not resolve by resting or relaxing and lasting at least 3 months.
RESULTS: The prevalence of prolonged fatigue was 3.0% (SE=0.3), with 1.4% (SE=0.2) for prolonged fatigue only and 1.6% (SE=0.2) for prolonged fatigue concomitant with a depressive or anxiety disorder. Nearly 60% of the adolescents with prolonged fatigue only had severe or very severe disability, and their rates of poor physical and mental health were comparable to those of adolescents with mood or anxiety disorders only. Adolescents with prolonged fatigue and comorbid mood or anxiety disorders had significantly greater disability, poorer mental health, and more health service use than those with either condition alone.
CONCLUSIONS: These findings suggest that prolonged fatigue is associated with disability and is an important clinical entity independent of mood and anxiety disorders in adolescents. Persistent fatigue with a comorbid mood or anxiety state is related to even more functional impairment, suggesting that prolonged fatigue may reflect greater severity of mood and anxiety disorders in adolescents.
Femke Lamers; Ian Hickie; Kathleen R Merikangas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  170     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-01     Completed Date:  2013-06-28     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502-10     Citation Subset:  AIM; IM    
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MeSH Terms
Adolescent Behavior / psychology*
Anxiety / epidemiology*,  psychology
Chronic Disease / epidemiology,  psychology
Depression / epidemiology*,  psychology
Diagnostic Self Evaluation
Fatigue / epidemiology*,  psychology
Health Surveys
Sex Characteristics
United States / epidemiology
Grant Support
Comment In:
Am J Psychiatry. 2013 May;170(5):459-61   [PMID:  23632830 ]

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