| Prevalence and correlates of GB virus C infection in HIV-infected and HIV-uninfected pregnant women in Bangkok, Thailand. | |
| | |
MedLine Citation:
|
PMID: 21108337 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
GB virus C (GBV-C) is an apathogenic virus that has been shown to inhibit HIV replication. This study examined the prevalence and correlates of GBV-C infection and clearance in three cohorts of pregnant women in Thailand. The study population consisted of 1,719 (1,387 HIV-infected and 332 HIV-uninfected) women from three Bangkok perinatal HIV transmission studies. Stored blood was tested for GBV-C RNA, GBV-C antibody, and if RNA-positive, genotype. Risk factors associated with the prevalence of GBV-C infection (defined as presence of GBV-C RNA and/or antibody) and viral clearance (defined as presence of GBV-C antibody in the absence of RNA) among women with GBV-C infection were examined using multiple logistic regression. The prevalence of GBV-C infection was 33% among HIV-infected women and 15% among HIV-uninfected women. GBV-C infection was independently associated (AOR, 95% CI) with an increasing number of lifetime sexual partners (referent-1 partner, 2 partners [1.60, 1.22-2.08], 3-10 partners [1.92, 1.39-2.67], >10 partners [2.19, 1.33-3.62]); injection drug use (5.50, 2.12-14.2); and HIV infection (3.79, 2.58-5.59). Clearance of GBV-C RNA among women with evidence of GBV-C infection was independently associated with increasing age in years (referent <20, 20-29 [2.01, 1.06-3.79] and ≥30 [3.18, 1.53-6.60]), more than 10 lifetime sexual partners (3.05, 1.38-6.75), and HIV infection (0.29, 0.14-0.59). This study found that GBV-C infection is a common infection among Thai women and is associated with HIV infection and both sexual and parenteral risk behaviors. |
| | |
Authors:
|
Wendy Bhanich Supapol; Robert S Remis; Janet Raboud; Margaret Millson; Jordan Tappero; Rupert Kaul; Prasad Kulkarni; Michelle S McConnell; Philip A Mock; Janet M McNicholl; Anuvat Roongpisuthipong; Tawee Chotpitayasunondh; Nathan Shaffer; Salvatore Butera |
Related Documents
:
|
10741077 - Chronic liver disease among u.s. military patients: the role of hepatitis c and g virus... 12935737 - Camel trypanosomosis in morocco. 2. a pilot disease control trial. 9237707 - Effect of interferon-alpha and ribavirin therapy on serum gb virus c/hepatitis g virus ... 16741887 - Incidence of guillain-barré syndrome among patients with campylobacter infection: a ge... 12222367 - Prevention of hiv transmission from mother-to-child. 1584157 - The result of an educational intervention for physicians providing hiv-antibody testing... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of medical virology Volume: 83 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
|
Languages: eng Pagination: 33-44 Citation Subset: IM |
Copyright Information:
|
© 2010 Wiley-Liss, Inc. |
Affiliation:
|
Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. supapol@cogeco.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
5 R21 AI060538/AI/NIAID NIH HHS; HP 64515//Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential gene expression of soluble CD8+ T-cell mediated suppression of HIV replication in three...
Next Document: A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions as...