Document Detail

Prevalence of coronary artery disease in Japanese patients with cerebral infarction: impact of metabolic syndrome and intracranial large artery atherosclerosis.
MedLine Citation:
PMID:  18296836     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with cerebral infarction have a high prevalence of asymptomatic coronary artery disease (CAD) and other vascular diseases, but there is a lack of such data for Japanese patients, so the present study investigated the prevalence of cardiovascular disease (CVD) in Japanese patients and determined the predictors of CAD. METHODS AND RESULTS: The study group comprised 104 patients with cerebral infarction who had no history of CVD. All patients underwent coronary computed tomographic angiography, and systematic evaluation was done on the basis of the presence of other vascular diseases, CVD risk markers, and the degree of atherosclerosis. Of the total, 39 patients (37.5%) had CAD, 9 (8.7%) had carotid artery stenosis, 9 (8.7%) had peripheral artery disease of the lower limbs, and 3 (2.9%) had atherosclerotic renal artery stenosis. Multiple regression analysis showed that the presence of CAD was independently associated with metabolic syndrome (odds ratio (OR) 5.008, 95% confidence interval (CI) 1.538-16.309; p<0.01) and intracranial large artery atherosclerosis (OR 4.979, 95% CI 1.633-15.183; p<0.01). CONCLUSION: Japanese patients with cerebral infarction have a high prevalence of CVD, especially asymptomatic CAD. Both metabolic syndrome and intracranial large artery atherosclerosis may be potential predictors for identifying patients with cerebral infarction who are at the highest risk of asymptomatic CAD.
Atsushi Hoshino; Takashi Nakamura; Satoko Enomoto; Hiroyuki Kawahito; Hiroyuki Kurata; Yoshifumi Nakahara; Toshiharu Ijichi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  404-8     Citation Subset:  IM    
Department of Cardiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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MeSH Terms
Carotid Stenosis / epidemiology
Cerebral Infarction / epidemiology*,  ethnology
Coronary Angiography
Coronary Artery Disease / epidemiology*
Intracranial Arteriosclerosis / epidemiology*,  ethnology
Metabolic Syndrome X / epidemiology*,  ethnology
Middle Aged
Peripheral Vascular Diseases / epidemiology
Predictive Value of Tests
Regression Analysis
Renal Artery Obstruction / epidemiology
Retrospective Studies
Risk Factors

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