Document Detail

Prevalence of coronary artery calcium scores and silent myocardial ischaemia was similar in Indian Asians and European whites in a cross-sectional study of asymptomatic subjects from a U.K. population (LOLIPOP-IPC).
MedLine Citation:
PMID:  21479755     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coronary heart disease (CHD) mortality is 70% higher among Indian Asians (IA) than European whites (EW), the reasons for this excess remain unexplained. Coronary artery calcification (CAC) is highly correlated with coronary plaque burden and silent myocardial ischaemia in EW; but fails to identify excess risk in IA. We hypothesised that IA have a higher prevalence of silent myocardial ischaemia compared to EW, despite similar CAC, and this may explain their excess CHD mortality.
METHODS: CAC was measured for 2,369 asymptomatic men and women, aged 35 to 75 years, as part of the London Life Sciences Population (LOLIPOP) study. 518 subjects had CAC scores >100 Agatston units and of these 256 (49%) patients underwent myocardial perfusion scintigraphy (MPS).
RESULTS: CAC scores were similar among IA and EW, after adjustment for conventional risk factors. MPS abnormalities were seen in 56 (22%) subjects. Presence of diabetes (P = .03) and increasing CAC (P < .001) were independent predictors for severity of silent myocardial ischaemia. Ethnicity did not influence the prevalence or the extent of silent myocardial ischaemia.
CONCLUSION: MPS did not identify greater ischaemia among IA compared with EW. This appears incongruent with almost 2-fold higher risk of CHD mortality observed in IA.
Piyush Jain; Jaspal S Kooner; Usha Raval; Avijit Lahiri
Related Documents :
21385355 - Six sequence variants on chromosome 9p21.3 are associated with a positive family histor...
6667015 - Serum ck-mb isoenzyme after aortic and mitral valve replacements.
21519225 - Short-term minoxidil use associated with pericardial effusion and cardiac tamponade: an...
21299845 - A multicenter, prospective, randomized, controlled trial evaluating the safety and effi...
1166855 - Idiopathic ventricular tachycardia. an intracardiac electrical, hemodynamic and angiogr...
7818025 - Left ventricular structure and function by echocardiography in congenital muscular dyst...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-09
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  18     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-18     Completed Date:  2011-09-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  435-42     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcinosis / diagnosis,  ethnology*
Coronary Artery Disease / diagnosis,  ethnology*
Cross-Sectional Studies
Europe / ethnology
Great Britain / ethnology
India / ethnology
Middle Aged
Myocardial Ischemia / diagnosis,  ethnology*
Myocardial Perfusion Imaging / statistics & numerical data
Risk Assessment
Risk Factors
Grant Support
G0601966//Medical Research Council; G0700931//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts.
Next Document:  Left ventricular dyssynchrony in patients with end-stage liver disease.