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Prevalence of congenital heart disease at live birth: an accurate assessment by echocardiographic screening.
MedLine Citation:
PMID:  23350618     Owner:  NLM     Status:  Publisher    
AIMS: To determine the true prevalence of congenital heart disease (CHD) at live birth using echocardiographic screening. METHODS: A total of 5190 consecutive newborns from two secondary hospitals were included. Each neonate had a complete clinical evaluation with echocardiographic diagnosis at average 47 hours of age. Newborns with persistent CHD underwent at least 4 months follow-up, the temporal trend of prevalence of mild CHD was assessed. RESULTS: Overall live birth prevalence of CHD was 26.6‰ (severe 3.5‰, moderate 5.4‰, mild 17.7‰) and prevalence of CHD that could be detected by clinical evaluation was 12.1‰. The most common CHD was ventricular septal defect (VSD, 17.3‰), followed by atrial septal defect (ASD, 6.2‰), patent ductus arteriosus (PDA, 1.3‰), tetralogy of Fallot (TOF, 0.4‰), single ventricle (SV, 0.4‰), atrioventricular septal defect (AVSD, 0.2‰) and double outlet right ventricle (DORV, 0.2‰) . Female predominance was observed in mild CHD (VSD, ASD); and male predominance was observed in severe CHD. The prevalence of CHD was reduced to 19.5‰ at the 4 months follow-up, which was largely caused by spontaneous closure rate of muscular VSD. CONCLUSION: Prevalence of CHD determined by echocardiography screening was higher but more accurate than that obtained from birth defect registries. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Quming Zhao; Xiaojing Ma; Bing Jia; Guoying Huang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-25
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
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