| Prevalence and clinical significance of antiribosomal P antibody in childhood-onset systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 22740428 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To investigate the prevalence of the anti-ribosomal P (anti-P) antibodies in childhood-onset systemic lupus erythematosus patients (cSLE), healthy controls and first degree relatives. To elucidate the association between anti-P and disease activity, laboratory and treatment features in cSLE patients. Methods: We included consecutive SLE patients with disease onset before 16 years. Controls were age- and sex-matched. SLE patients were assessed for clinical and laboratory SLE manifestations, disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)) and current drug exposures. Mood disorders were determined through Becks Depression and Becks Anxiety Inventory. Anti-P measured by enzyme-linked immunosorbent assay. Results: We included 50 consecutive cSLE patients (mean age of 16.82 ± 3.46 years), 35 first degree relatives (mean age of 38.73 ± 3.89 years) and 20 health control (mean age of 18.3 ± 4.97 years). Anti-P was observed in 13 (26%) cSLE patients and in no first-degree relative (p < 0.01) or control (p < 0.01). Anti-P was more frequently observed in patients with anxiety (p < 0.002). No other clinical, laboratory or treatment features, including SLEDAI and SDI scores were associated with the presence of anti-P in cSLE patients. Conclusion: Anti-P is frequently observed in cSLE patients and was associated with the presence of anxiety in this cohort of cSLE. |
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Authors:
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H Aldar; At Lapa; B Belini; Na Sincinato; M Postal; Pt Fernandes; Ltl Costallat; R Marini; S Appenzeller |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-27 |
Journal Detail:
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Title: Lupus Volume: - ISSN: 1477-0962 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Rheumatology Unit, Faculty of Medical Science, State University of Campinas, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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