Document Detail


Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus.
MedLine Citation:
PMID:  20694751     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
INTRODUCTION: It is necessary to assay multiple autoantibodies simultaneously in the same group of new-onset systemic lupus erythematosus (SLE) patient.
AIM: To determine the prevalence and clinical significance of 15 autoantibodies in patients with new-onset SLE.
METHODS: Twenty new-onset patients with SLE and 32 healthy individuals were enrolled in the present study. Serum levels of 15 autoantibodies were detected by enzyme linked immunosorbent assay. The clinical parameters of the patients were also recorded.
RESULTS: The positive rate of anti-ssDNA was the highest (85%). The positive rates of anti-dsDNA, anti-ssDNA, AHA, anti-SSA, anti-SSB, anti-Sm, anti-U1RNP, AnuA, and rRNP were significantly higher in SLE patients than in nomal controls. In terms of clinical manifestation, there were significant associations of rRNP with photaesthesia and of AHA with nephritis.
CONCLUSION: Clusters of autoantibodies were identified and associations of antibodies with symptoms were found in new-onset patients with SLE.
Authors:
W-X Li; H-F Pan; L-H Li; N Zhang; J Li; Y-G Fan; J-B Feng; X-W Tang; H Chen; X-P Li; D-Q Ye
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-08
Journal Detail:
Title:  Irish journal of medical science     Volume:  179     ISSN:  1863-4362     ISO Abbreviation:  Ir J Med Sci     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  623-7     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
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