| Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease. | |
| | |
MedLine Citation:
|
PMID: 20624775 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Abnormally low serum testosterone levels were recently associated with an increased mortality risk in male dialysis patients. However, the prevalence of testosterone deficiency in end-stage renal disease (ESRD) is not well defined. We hereby explore the prevalence and correlates of clinical testosterone deficiency in a large cohort of ESRD male patients. METHODS: Two hundred and sixty ESRD men [median age 59 (25th-75th percentile 48-67) years] were included. Testosterone concentration and testosterone deficiency (<10 nmol/L) were studied in relation to clinically evident cardiovascular disease and markers of inflammation at baseline as well as deaths registered during the following 36 months. RESULTS: Testosterone deficiency was present in 44% of the patients, while 33% showed testosterone insufficiency (10-14 nmol/L), and only 23% had normal testosterone values (>14 nmol/L). Testosterone was strongly and inversely correlated to inflammatory markers (CRP, IL-6 and fibrinogen), even after correction for age and sex hormone-binding globulin. In a crude spline curve, low testosterone concentrations were associated with worse outcome. A clinical condition of testosterone deficiency was independently associated with cardiovascular co-morbidity [odds ratio (OR) 2.51; 95% confidence interval (CI) 1.32-4.76] and death (OR 2.00; 95% CI 1.01-3.97) in logistic regression analyses. CONCLUSIONS: Testosterone deficiency is a common finding among male ESRD patients, and it is independently associated with inflammation, cardiovascular co-morbidity and outcome. Future studies are needed to determine the potential adverse effects of male hypogonadism in ESRD and the possibility of improving risk profile, quality of life, and ultimately outcome with testosterone supplementation in these patients. |
| | |
Authors:
|
Juan Jesús Carrero; Abdul Rashid Qureshi; Ayumu Nakashima; Stefan Arver; Paolo Parini; Bengt Lindholm; Peter Bárány; Olof Heimbürger; Peter Stenvinkel |
Related Documents
:
|
14634545 - Decision analysis of hormone replacement therapy after the women's health initiative. 21747715 - Oral hpv infection and sexuality: a cross-sectional study in women. 12007905 - Androgen deficiency: menopause and estrogen-related factors. 7705325 - Androgen administration to aging men. 8886765 - Men's perceptions of their roles and responsibilities regarding sex, contraception and ... 22345315 - Smoking of parents and best friend--independent and combined effects on adolescent smok... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-11 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
|
Languages: eng Pagination: 184-90 Citation Subset: IM |
Affiliation:
|
Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden. juan.jesus.carrero@ki.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidence of renal replacement therapy (RRT) in the diabetic compared with the non-diabetic populati...
Next Document: Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in pa...