Document Detail


Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome.
MedLine Citation:
PMID:  14601646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-beta2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-beta2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six beta2GPI-related peptides. A high degree of simultaneous reactivity against several beta2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the beta2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.
Authors:
Y Shoenfeld; I Krause; F Kvapil; J Sulkes; S Lev; P von Landenberg; J Font; J Zaech; R Cervera; J C Piette; M C Boffa; M A Khamashta; M L Bertolaccini; G R V Hughes; P Youinou; P L Meroni; V Pengo; J D Alves; A Tincani; G Szegedi; G Lakos; G Sturfelt; A Jönsen; T Koike; M Sanmarco; A Ruffatti; Z Ulcova-Gallova; S Praprotnik; B Rozman; M Lorber; V B Vriezman; M Blank
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  23     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-11-06     Completed Date:  2004-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-83     Citation Subset:  IM    
Affiliation:
Department of Medicine "B", Sheba Medical Center, Tel-Hashomer, Israel. shoenfel@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amino Acid Sequence
Antibodies / immunology*
Antiphospholipid Syndrome / etiology,  immunology*
Glycoproteins / chemistry,  immunology*
Humans
Lupus Erythematosus, Systemic / complications,  immunology
Middle Aged
Molecular Sequence Data
Peptides / chemistry*,  immunology*
beta 2-Glycoprotein I
Chemical
Reg. No./Substance:
0/Antibodies; 0/Glycoproteins; 0/Peptides; 0/beta 2-Glycoprotein I

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