| Prevalence and clinical correlates of isolated mitral, isolated aortic regurgitation, and both in adults aged 21 to 35 years (from the CARDIA study). | |
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MedLine Citation:
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PMID: 17350376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aortic regurgitation (AR) and mitral regurgitation (MR) can result in serious clinical complications and death. The physiologic and clinical correlates of AR and MR in a free-living young adult population, however, have not been well defined. The prevalence and correlates of AR and MR were investigated in Coronary Artery Risk Development in Young Adults (CARDIA), a multicenter National Heart, Lung, and Blood Institute study of 4,352 men and women aged 21 to 35 years who had 2-dimensionally directed M-mode echocardiographic and spectral and color Doppler examinations. Isolated MR by color Doppler was detected in 10.4% (90.4% with trivial or mild severity). Isolated AR by color Doppler was present in 0.8% (37.7% with mild severity). Combined AR and MR occurred in 0.5%. There was no association between body mass index and the prevalence or severity of MR or AR. Left ventricular mass was greater in subjects with isolated AR (mean +/- SD 172 +/- 49 g) than in those with MR (155 +/- 48 g) and greater in both groups than in subjects without MR and AR (148 +/- 44 g). AR was associated with increased aortic root diameter, whereas subjects with isolated MR and those with AR and MR had increased left atrial dimensions and greater left ventricular internal dimensions. In conclusion, MR and AR detected by color Doppler echocardiography are relatively uncommon in a healthy young adult population, but both are associated with evidence of increased left ventricular dimensions and mass. |
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Authors:
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Cheryl L Reid; Hoda Anton-Culver; Carla Yunis; Julius M Gardin |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural Date: 2007-01-30 |
Journal Detail:
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Title: The American journal of cardiology Volume: 99 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-04-26 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 830-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Division of Epidemiology, University of California, Irvine, Irvine, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Valve Insufficiency / complications, epidemiology*, pathology, ultrasonography Cohort Studies Echocardiography, Doppler, Color Female Humans Incidence Male Mitral Valve Insufficiency / complications, epidemiology*, pathology, ultrasonography Prevalence Severity of Illness Index United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC 48047/HC/NHLBI NIH HHS; N01-HC 48048/HC/NHLBI NIH HHS; N01-HC 48049/HC/NHLBI NIH HHS; N01-HC 48050/HC/NHLBI NIH HHS; N01-HC 95095/HC/NHLBI NIH HHS; N01-HC 95100/HC/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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