Document Detail

Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques.
MedLine Citation:
PMID:  15567875     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study analyses the prevalence of karyotype changes and Yq11 microdeletions among couples referred for assisted reproduction techniques. METHODS: Prior to receiving either IVF or ICSI treatment, each partner of 2078 infertile couples was screened for karyotype changes by GTG-banding technique on peripheral lymphocytes. No subject presented with obvious phenotype of chromosomal rearrangement. All the oligo/azoospermic men with normal karyotype were further investigated by PCR for Yq11 microdeletions. RESULTS: Eighty-two out of 2078 couples (3.95%) had one partner carrying a chromosomal change, and 10 out of 202 (4.95%) men showed Yq11 microdeletions. The chromosomal rearrangements were 44 (2.1%) translocations, 23 (1.1%) gonosomal mosaics, six (0.3%) 47,XXY, five (0.24%) marker chromosomes, three (0.14%) inversions and one (0.05%) duplication. Frequency of anomalies in men and women were similar: 42 and 40 cases respectively. CONCLUSIONS: Partners of infertile couples requiring IVF or ICSI treatment appear to be affected by higher frequency of chromosomal rearrangements than the general population. Categories with greater risk were represented by men with sperm cell count <20 x 10(6) sperm/ml, and women with history of pregnancy loss.
E Clementini; C Palka; I Iezzi; L Stuppia; P Guanciali-Franchi; G M Tiboni
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Publication Detail:
Type:  Journal Article     Date:  2004-11-26
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell'Invecchiamento, Facoltà di Medicina e Chirurgia, Università G.d'Annunzio, Ospedale SS. Annunziata, Via dei Vestini, 66013-Chieti and ITOI-CNR, Bologna, Italy.
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MeSH Terms
Chromosome Aberrations / statistics & numerical data*
Cohort Studies
Infertility, Female / epidemiology*,  genetics*
Infertility, Male / epidemiology*,  genetics*
Middle Aged
Pregnancy Outcome / epidemiology
Risk Factors

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