Document Detail


Prevalence of celiac disease: multicentric trial among pediatric population from five urban districts in Argentina.
MedLine Citation:
PMID:  23224306     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction. No published material on the preva lence of celiac disease (CD) in the pediatric population of Argentina has been found up to date. Objective. To estimate the prevalence of CD in a pediatric population (hospital-based sample) from 5 urban districts of Argentina. Methods. In a cross-sectional descriptive study, we analyzed serum samples from 2219 children, aged 3-16 years old, which had been requested for pre-surgical tests and for physical aptitude certifcates for sports in the province of Buenos Aires, and cities of Buenos Aires, Córdoba, Santa Fe and Salta. Children with a previous and accurate diagnosis of CD were also included. IgA class tissue transglu taminase antibodies were determined using serum samples, and those samples which turned out positive were also tested for IgA class endomysium an tibodies. A small intestine biopsy was proposed for those who had a positive serology. Results. Between May 2008 and August 2009, 29 positive serologies were found. A total of 22 duo denum biopsies were performed, and 21 turned out compatible with CD. Out of 2219 children, 7 had a previous diagnosis. A prevalence of 1.26% (1:79 children), with female gender predominance (p < 0.023) was found. Ninety percent of the celiac children were over 6 years old (p < 0.021). Silent celiac disease predominated but there was a 33% of symptomatic cases. Conclusions. The results of the trial show a higher prevalence of CD than expected. The finding of symptomatic patients (33%) suggests the undertak ing of different activities to spread the knowledge on this disease and promote the indication for serology test, to avoid complications by means of an early diagnosis.
Authors:
Mabel Mora; Néstor Litwin; María Del Carmen Toca; María Inés Azcona; Rossana Solís Neffa; Fernando Battiston; María Solaegui; Gonzalo Ortiz; Marta Wagener; Jorgelina Olivera; Silvia Marchisone; Gabriela Oropeza; Cinthia Bastianelli; Alejandra González; Gabriela Rezzónico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivos argentinos de pediatría     Volume:  110     ISSN:  1668-3501     ISO Abbreviation:  Arch Argent Pediatr     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372460     Medline TA:  Arch Argent Pediatr     Country:  Argentina    
Other Details:
Languages:  eng; spa     Pagination:  490-6     Citation Subset:  IM    
Affiliation:
Hospital Materno Infantil de San Isidro Dr. Carlos Gianantonio.
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