Document Detail


Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil.
MedLine Citation:
PMID:  23018296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied.
METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy.
RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain.
CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.
Authors:
Marília Lage Alencar; Carmen Lucia Ortiz-Agostinho; Lêda Nishitokukado; Adérson O M C Damião; Clarice P Abrantes-Lemos; André Zonetti de Arruda Leite; Thales de Brito; Dalton de Alencar Fischer Chamone; Maria Elizabeth Rossi da Silva; Daniel Giannella-Neto; Aytan Miranda Sipahi
Related Documents :
17195806 - Orthopaedic complications of myotubular myopathy.
2298356 - Polypoid menetrier's disease associated with acromegaly.
24246986 - Endoscopy as a prognostic marker in inflammatory bowel disease.
18985546 - Male adnexal tumour of wolffian origin: the first report of metastatic disease.
6306336 - Respiratory disease associated with parainfluenza type i (sendai) virus in a colony of ...
20298806 - Mechanisms of intestinal inflammation and development of associated cancers: lessons le...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  67     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-06-19     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1013-8     Citation Subset:  IM    
Affiliation:
Laboratorio de Gastroenterologia Clínica e Experimental - LIM 07, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Banks
Blood Donors / statistics & numerical data*
Brazil / epidemiology
Celiac Disease / epidemiology*,  ethnology
Cities / epidemiology
Continental Population Groups / statistics & numerical data
Epidemiologic Methods
Female
Humans
Immunoglobulin A / blood
Male
Middle Aged
Transglutaminases / blood
Young Adult
Chemical
Reg. No./Substance:
0/Immunoglobulin A; EC 2.3.2.13/Transglutaminases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reduced salivary flow and colonization by mutans streptococci in children with Down syndrome.
Next Document:  Evaluation of the mean platelet volume in patients with cardiac syndrome X.