Document Detail


Prevalence and causes of undiagnosed hyperthyroidismin an adult healthy population. The Tromsø study.
MedLine Citation:
PMID:  19092288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The causes of subclinical hyperthyroidism have only been reported from clinical studies.
AIM: To determine the prevalence and pathological causes of reduced serum TSH levels in subjects recruited from an epidemiological survey.
MATERIAL/SUBJECTS AND METHODS: Serum TSH was measured in 7954 subjects in the 5th Tromsø study. Subjects with serum TSH<0.50 mIU/l, not using T4, without a previous diagnosis of thyroid disease, without serious concomitant disease, and younger than 80 yr, were invited for a re-examination. If low serum TSH was persistent, thyroid scintigraphy was performed.
RESULTS: Among the 4962 subjects that met the inclusion criteria, serum TSH was <0.50 mIU/l in 105 subjects. Twelve subjects had a suppressed serum TSH level (<0.05 mIU/l). Two of these were lost to follow-up, 4 had Graves' disease, 4 had adenoma, and 2 had multinodular goiter. In the 93 subjects with serum TSH 0.05-0.5 mIU/l, 55 were re-examined, of whom 35 had normalized their serum TSH level. In the remaining 20 subjects, 1 had Graves' disease, 6 had adenoma (of which 2 were toxic adenomas), 7 had multinodular goiter, and 6 were considered normal. Among the 521 subjects using T4, 70 (13.4%) had a suppressed serum TSH level.
CONCLUSIONS: Most of the subjects with a suppressed serum TSH level will be on T4 medication. Otherwise, if the suppressed serum TSH level is found by chance, this probably represents a clinically important thyroid pathology. Also, in subjects with a persistently low serum TSH level (0.05-0.5 mIU/l) most will have a pathological thyroid scan.
Authors:
M M Bjørndal; K Sandmo Wilhelmsen; T Lu; R Jorde
Related Documents :
6165878 - Pharmacological interference with in vitro tests of thyroid function.
2120878 - Turnover of thyrotropin-releasing hormone in patients with chronic renal failure and ch...
16645008 - Is there a need to redefine the upper normal limit of tsh?
3932818 - Alterations in circulating thyroid hormones and thyrotropin in euthyroid patients with ...
3904908 - Plasma hormone levels in patients with prostatic carcinoma treated with diethylstilboes...
2379418 - Ice nucleating activity in the blood of the freeze-tolerant frog, rana sylvatica.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  31     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-02-27     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  856-60     Citation Subset:  IM    
Affiliation:
Institute of Clinical Medicine, University of Tromsø, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoma / complications
Adult
Aged
Cohort Studies
Female
Goiter, Nodular / complications
Graves Disease / complications
Health Surveys
Humans
Hyperthyroidism / epidemiology*,  etiology,  radionuclide imaging
Male
Middle Aged
Norway / epidemiology
Prevalence
Sodium Pertechnetate Tc 99m / diagnostic use
Thyroid Gland / radionuclide imaging
Thyroid Neoplasms / complications
Thyrotropin / blood*
Thyroxine / therapeutic use
Chemical
Reg. No./Substance:
23288-60-0/Sodium Pertechnetate Tc 99m; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Iodine status and thyroid volume changes during pregnancy: results of a survey in Aran Valley (Catal...
Next Document:  Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders.