Document Detail


Prevalence of capsular serotypes among Staphylococcus aureus isolates from cows with mastitis in the United States.
MedLine Citation:
PMID:  9460196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of an appropriate Staphylococcus aureus vaccine for bovine mastitis has eluded researchers for decades. The ability of S. aureus to form a protective exopolysaccharide capsule has posed a major obstacle because of the multiple serotypes and the poor immune response elicited by exopolysaccharides. This study characterized S. aureus serotypes isolated from cases of bovine mastitis obtained from veterinary diagnostic laboratories that service 44% of the dairy cattle in the United States. Major milk producing areas of the northeast, north central, Pacific coast and southwest were proportionately represented. Sub-samples of mastitic milk that contained S. aureus were frozen and sent to our laboratory for strain serotyping. The only other regional serotyping of S. aureus from bovine mastitis to date was done in France. The primary serotypes found were types 5 (51%) and 8 (18%) and 31% were non-typeable. In the current study, serotype 5 accounted for 18% of the isolates and serotype 8 for 23%. More importantly 59% of the isolates were not typeable with either type 5 or 8 antisera. These data indicate that S. aureus vaccines employing serotypes 5 and 8 would only be marginally effective in the United States. These data also suggest that development of a S. aureus vaccine for bovine mastitis should take into account regional variation in S. aureus serotypes.
Authors:
A Guidry; A Fattom; A Patel; C O'Brien
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary microbiology     Volume:  59     ISSN:  0378-1135     ISO Abbreviation:  Vet. Microbiol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-23     Completed Date:  1998-03-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
Affiliation:
Immunology and Disease Resistance Laboratory, USDA-ARS, Beltsville, MD 20705, USA. aguidry@ggpl.arsusda.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Vaccines
Cattle
Female
France
Geography
Mastitis, Bovine / microbiology*
Milk / microbiology*
Serotyping
Staphylococcal Infections / microbiology,  veterinary*
Staphylococcus aureus / classification*,  isolation & purification
United States
Chemical
Reg. No./Substance:
0/Bacterial Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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