Document Detail

Prevalence of birth defects and parental work in Singapore live births from 1994 to 1998: a population-based study.
MedLine Citation:
PMID:  12361994     Owner:  NLM     Status:  MEDLINE    
The aims of the study were to assess the prevalence of birth defects (BDs) among different occupational groups and non-working parents, and to identify possible risk factors associated with BDs in Singapore live births born between 1 January 1994 and 31 December 1998. To do this, information on live births (from the Singapore National Registry of Births and Deaths) and BD cases [from the National Birth Defects Register (NBDR)] was obtained from 1 January 1994 to 31 December 1998. There were a total of 237 755 live births in Singapore between 1 January 1994 and 31 December 1998. Over the same period, 3293 cases of BDs were reported to the NBDR, giving an overall rate of 13.9 per 1000 live births. A downward trend with time was noted. Of the live born with BDs in this series, 36.7% presented with multiple anomalies. The overall occurrence of malformation (per 1000 live births) among working versus non-working mothers was 13.4 versus 14.2, respectively, and 13.8 for working fathers compared with 16.8 for non-working fathers. Parents in the occupational group 'Legislators, Senior Officers & Managers' had the lowest prevalence rates of congenital anomalies (9.4 per 1000 for mothers and 10.3 per 1000 for fathers), while the 'Agricultural & Fishery Workers' had the highest rates (40.0 per 1000 for mothers and 23.4 per 1000 for fathers). However, the very small number of workers in this latter group makes the rate unreliable. The prevalence of BDs in Singapore is comparable to those in other countries. Parental work per se is not correlated with BDs.
L M Shi; S E Chia; O Y Chan; S K Chew; B H Foong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Occupational medicine (Oxford, England)     Volume:  52     ISSN:  0962-7480     ISO Abbreviation:  Occup Med (Lond)     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-03     Completed Date:  2002-11-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205857     Medline TA:  Occup Med (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Department of Community, Occupational & Family Medicine, National University of Singapore.
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MeSH Terms
Congenital Abnormalities / epidemiology*,  etiology
Cross-Sectional Studies
Maternal Exposure / adverse effects,  statistics & numerical data*
Occupational Exposure / adverse effects,  statistics & numerical data*
Paternal Exposure / adverse effects,  statistics & numerical data*
Pregnancy Outcome
Risk Factors
Singapore / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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