Document Detail


Prevalence of birth defects among infants of Gulf War veterans in Arkansas, Arizona, California, Georgia, Hawaii, and Iowa, 1989-1993.
MedLine Citation:
PMID:  12854660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidemiologic studies of birth defects among infants of Gulf War veterans (GWV) have been limited to military hospitals, anomalies diagnosed among newborns, or self-reported data. This study was conducted to measure the prevalence of birth defects among infants of GWVs and nondeployed veterans (NDV) in states that conducted active case ascertainment of birth defects between 1989-93. METHODS: Military records of 684,645 GWVs and 1,587,102 NDVs were electronically linked with 2,314,908 birth certficates from Arizona, Hawaii, Iowa, and selected counties of Arkansas, California, and Georgia; 11,961 GWV infants and 33,052 NDV infants were identified. Of these, 450 infants had mothers who served in the Gulf War, and 3966 had NDV mothers. RESULTS: Infants conceived postwar to male GWVs had significantly higher prevalence of tricuspid valve insufficicieny (relative risk [RR], 2.7; 95% confidence interval [CI], 1.1-6.6; p = 0.039) and aortic valve stenosis (RR, 6.0; 95% CI, 1.2-31.0; p = 0.026) compared to infants conceived postwar to NDV males. Among infants of male GWVs, aortic valve stenosis (RR, 163; 95% CI, 0.09-294; p = 0.011) and renal agenesis or hypoplasia (RR, 16.3; 95% CI, 0.09-294; p = 0.011) were significantly higher among infants conceived postwar than prewar. Hypospadias was significantly higher among infant sons conceived postwar to GWV women compared to NDV women (RR, 6.3; 95% CI, 1.5-26.3; p = 0.015). CONCLUSION: We observed a higher prevalence of tricuspid valve insufficiency, aortic valve stenosis, and renal agenesis or hypoplasia among infants conceived postwar to GWV men, and a higher prevalence of hypospadias among infants conceived postwar to female GWVs. We did not have the ability to determine if the excess was caused by inherited or environmental factors, or was due to chance because of myriad reasons, including multiple comparisons. Although the statistical power was sufficient to compare the combined birth defects prevalence, larger sample sizes were needed for less frequent individual component defects.
Authors:
Maria Rosario G Araneta; Karen M Schlangen; Larry D Edmonds; Daniel A Destiche; Ruth D Merz; Charlotte A Hobbs; Timothy J Flood; John A Harris; Diane Krishnamurti; Gregory C Gray
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  67     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-07-11     Completed Date:  2004-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-60     Citation Subset:  IM    
Affiliation:
Department of Defense Center for Deployment Health Research, Naval Health Research, Center, San Diego, California, USA. haraneta@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Arizona / epidemiology
Arkansas / epidemiology
California / epidemiology
Case-Control Studies
Congenital Abnormalities / epidemiology*
Female
Georgia / epidemiology
Hawaii / epidemiology
Humans
Infant, Newborn
Iowa / epidemiology
Male
Middle East
Military Personnel / statistics & numerical data*
Population Surveillance
Pregnancy
Pregnancy Outcome
Prevalence
Veterans / statistics & numerical data*
War*
Comments/Corrections
Comment In:
Birth Defects Res A Clin Mol Teratol. 2004 Jan;70(1):47; author reply 48-9   [PMID:  14745895 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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