Document Detail


Prevalence of antiphospholipid antibodies in Syrian patients with thrombosis.
MedLine Citation:
PMID:  19801789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antiphospholipid antibodies (aPL) are a heterogeneous family of antibodies associated with thrombosis and other complications. OBJECTIVE: To study the prevalence of aPL in patients with thrombosis at Aleppo University Hospitals, Syria. METHODS: One hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. Anticardiolipin antibodies (aCL) and Lupus anticoagulant (LA) were determined. RESULTS: Thirty-four out of 157 (21.7%) patients with thrombosis had some type of aPL. aPL was also found in four healthy subjects (4/63=6.3%). Eighteen patients (11.5%) were positive for LA, 20 (12.7%) for aCL antibodies and 4 (2.6%) were positive for more than one aPL. Patients without risk factors for thrombosis and having positive aPL were 23/34 (67.7%). Fourteen out of 78 (17.9%) patients with arterial thrombosis, and 20/79 (25.3%) with venous thrombosis were positive for at least one aPL. CONCLUSION: Our study showed a significant prevalence of aPL in patients with thrombosis. It seems that aPL is a risk factor for venous and arterial thrombosis, especially in patients with no conventional risk factors.
Authors:
Ali Deeb; Said Hamdoun; Khaled Dababo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Iranian journal of immunology : IJI     Volume:  6     ISSN:  1735-1383     ISO Abbreviation:  Iran J Immunol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282932     Medline TA:  Iran J Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  154-9     Citation Subset:  IM    
Affiliation:
Departments of Internal Medicine, Aleppo University, Syria. dr.alideeb@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Anticardiolipin / blood*
Antibodies, Antiphospholipid / blood*
Female
Humans
Lupus Coagulation Inhibitor / blood*
Male
Middle Aged
Seroepidemiologic Studies
Syria / epidemiology
Thrombosis / blood*,  diagnosis,  epidemiology
Young Adult
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antibodies, Antiphospholipid; 0/Lupus Coagulation Inhibitor

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