Document Detail


Prevalence of anticardiolipin antibody in isolated mitral or aortic regurgitation, or both, and possible relation to cerebral ischemic events.
MedLine Citation:
PMID:  1529945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anticardiolipin antibodies (acLa) are associated with a thrombotic tendency (often involving cerebral ischemic events), are frequently present with systemic lupus erythematosus and have been found together with cardiac valve abnormalities. Previous studies evaluated patients characterized by the presence of acLa or lupus, precluding assessment of the frequency of acLa in those with valvular disease. This study aims to establish the prevalence of acLa in patients with valve disease in the absence of lupus and, furthermore, to determine the influence of acLa on the risk of cerebral events in valve disease. Eighty-seven consecutive patients with mitral or aortic regurgitation, or both, prospectively underwent enzyme-linked immunosorbent assay testing for immunoglobulin G (IgG) and M acLa, as did 24 normal subjects. AcLa values greater than or equal to 3 SD above the normal mean were considered "positive." Prior cerebral events were defined retrospectively. Of 87 patients with valvular disease, 26 had positive IgG acLa levels compared with 0 of 24 normal subjects (p less than 0.01). AcLa values did not vary with valve disease etiology. Focal cerebral events had occurred in 8 patients and were embolic or probably embolic in 7, including 7 of 26 IgG acLa-positive and 1 of 60 IgG acLa-negative patients (p less than 0.001). In the absence of lupus, IgG acLa is highly prevalent among patients with aortic or mitral regurgitation, or both; this association may indicate a relatively high risk for cerebral emboli.
Authors:
D Barbut; J S Borer; A Gharavi; D Wallerson; R B Devereux; P Supino; N D Suite
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  70     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  901-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, New York Hospital-Cornell Medical Center, New York 10021.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aortic Valve Insufficiency / complications,  immunology*
Autoantibodies / analysis*
Brain Ischemia / complications,  immunology*
Cardiolipins / immunology*
Female
Humans
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Intracranial Embolism and Thrombosis / complications,  immunology
Ischemic Attack, Transient / complications,  immunology
Male
Middle Aged
Mitral Valve Insufficiency / complications,  immunology*
Prospective Studies
Retrospective Studies
Grant Support
ID/Acronym/Agency:
R01 HL25604/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Cardiolipins; 0/Immunoglobulin G; 0/Immunoglobulin M

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