| Prevalence of ankylosing spondylitis and its association with HL-A 27. | |
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MedLine Citation:
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PMID: 1206667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The close relationship between ankylosing spondylitis and the presence of the transplantation antigen HL-A 27 is well recognized. An attractive explanation for this has been that the gene coding for this antigen exists in marked linkage disequilibrium with an abnormal immune response gene. We have suggested, in contrast, that HL-A 27 may have a more direct importance because of a defective epistatic interaction between the gene coding for this antigen and a distinct disease susceptibility gene for AS, which may therefore be situated some distance from the major histocompatibility complex. |
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Authors:
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J S Percy; A S Russell |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 2 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-04-01 Completed Date: 1976-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 351-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Animals Gene Frequency HLA Antigens* Histocompatibility Antigens* Homozygote Humans Male Mice Spondylitis, Ankylosing / epidemiology*, genetics, immunology |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Histocompatibility Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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