Document Detail

Prevalence of ankylosing spondylitis and its association with HL-A 27.
MedLine Citation:
PMID:  1206667     Owner:  NLM     Status:  MEDLINE    
The close relationship between ankylosing spondylitis and the presence of the transplantation antigen HL-A 27 is well recognized. An attractive explanation for this has been that the gene coding for this antigen exists in marked linkage disequilibrium with an abnormal immune response gene. We have suggested, in contrast, that HL-A 27 may have a more direct importance because of a defective epistatic interaction between the gene coding for this antigen and a distinct disease susceptibility gene for AS, which may therefore be situated some distance from the major histocompatibility complex.
J S Percy; A S Russell
Related Documents :
6337447 - Comparative immunofluorescence of murine leukemia virus-derived membrane-associated ant...
9447977 - Isolation of developmentally regulated genes from toxoplasma gondii by a gene trap with...
19944017 - Role of telomere length in subtelomeric gene expression and its possible relation to ce...
8574397 - Role of the viab locus in synthesis, transport and expression of salmonella typhi vi an...
19379497 - A comparison of synthetic oligodeoxynucleotides, dna fragments and aav-1 for targeted e...
8093557 - The antennapedia-type homeobox genes have evolved from three precursors separated early...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  2     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  351-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Continental Ancestry Group
Gene Frequency
HLA Antigens*
Histocompatibility Antigens*
Spondylitis, Ankylosing / epidemiology*,  genetics,  immunology
Reg. No./Substance:
0/HLA Antigens; 0/Histocompatibility Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The treatment of gestational hypertension.
Next Document:  Size distribution of lymphocytes in juvenile rheumatoid arthritis.