Document Detail


Prevalence of ankylosing spondylitis and its association with HL-A 27.
MedLine Citation:
PMID:  1206667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The close relationship between ankylosing spondylitis and the presence of the transplantation antigen HL-A 27 is well recognized. An attractive explanation for this has been that the gene coding for this antigen exists in marked linkage disequilibrium with an abnormal immune response gene. We have suggested, in contrast, that HL-A 27 may have a more direct importance because of a defective epistatic interaction between the gene coding for this antigen and a distinct disease susceptibility gene for AS, which may therefore be situated some distance from the major histocompatibility complex.
Authors:
J S Percy; A S Russell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  2     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  351-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Animals
Gene Frequency
HLA Antigens*
Histocompatibility Antigens*
Homozygote
Humans
Male
Mice
Spondylitis, Ankylosing / epidemiology*,  genetics,  immunology
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Histocompatibility Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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