| Prevalence of alpha-chain variants at birth. | |
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MedLine Citation:
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PMID: 7457429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemoglobin electrophoresis of cord blood from 4,499 newborns was performed as part of a sickle cell disease detection program. Although the expected frequency of the genes for hemoglobins S and C were observed, six newborns (five kindreds) were heterozygous for an alpha G Hb. In four kindreds, the alpha chain variant was identified as Hb G-Philadelphia. In each case, heterozygosity for this Hb was manifested at birth by the presence of Hb F/G (alpha 2 G gamma 2), a slow Hb migrating between the positions of Hbs S and C on cellulose acetate. In some newborns, Hb G (alpha 2 G beta 2) was also detectable, so that these cord bloods had four hemoglobin components: F, F/G, A, and G. The prevalence of Hb G-Philadelphia in this population sample is higher than that usually reported for black Americans and may represent a founder effect. Comprehensive screening of cord blood hemoglobins should use electrophoresis on alkaline media as the primary testing procedure because it allows recognition of most variants, such as the D (G) hemoglobins. Reliable identification of Hbs S and C requires citrate agar electrophoresis as a confirmatory test. |
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Authors:
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O Castro; W P Winter; T C Lee; V E Headings |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of clinical pathology Volume: 75 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-03-27 Completed Date: 1981-03-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 56-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Protein Electrophoresis Fetal Blood / analysis* Hemoglobin, Sickle / analysis Hemoglobins / genetics Hemoglobins, Abnormal / analysis* Heterozygote Humans Infant, Newborn |
| Grant Support | |
ID/Acronym/Agency:
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15160//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin, Sickle; 0/Hemoglobins; 0/Hemoglobins, Abnormal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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