Document Detail

Prevalence of airway obstruction in the elderly: results from a cross-sectional spirometric study of nine age cohorts between the ages of 60 and 93 years.
MedLine Citation:
PMID:  20228994     Owner:  NLM     Status:  MEDLINE    
AIMS: To study the prevalence of airway obstruction according to age, gender and smoking habits using spirometry, and to compare the results using different definitions, classifications and spirometric reference values in an elderly population.
METHODS: A random sample of 2046 men and women in nine age cohorts (aged 60, 66, 72, 78, 81, 84, 87, 90 and 93 years) were drawn from the Swedish municipality registers. 1092 subjects performed spirometry of which 574 met ATS spirometric criteria.
RESULTS: According to GOLD criteria (FEV1/FVC <0.7) the prevalence of obstruction was 22.5% regardless of which one of three different spirometric reference values were used. Using the recently-changed Swedish National Guideline (SNG) recommendations--an FEV1/(F)VC ratio<0.7 in subjects younger than 65 years but an FEV1/(F)VC ratio<0.65 in subjects 65 years or older in order to define airway obstruction--the prevalence was 14.1% regardless of the applied spirometric reference values. Using the criterion FEV1/(F)VC < expected for age and gender (i.e. lower limit of normal, LLN) yielded the lowest prevalence of 10.1%.
CONCLUSIONS: The prevalence of pulmonary obstruction depends on the criteria used for defining airway obstruction and on which spirometric normal values are applied. Using an age-adjusted FEV1/(F)VC LLN quotient to define pulmonary obstruction can be recommended on the basis of our results.
Orsolya Szanto; Peter Montnemery; Solve Elmstahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Primary care respiratory journal : journal of the General Practice Airways Group     Volume:  19     ISSN:  1475-1534     ISO Abbreviation:  Prim Care Respir J     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121543     Medline TA:  Prim Care Respir J     Country:  England    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Department of Health Sciences, Division of Geriatric Medicine, Lund University, Malmo, Sweden.
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MeSH Terms
Age Factors
Aged, 80 and over
Airway Obstruction / diagnosis,  epidemiology*,  etiology
Cross-Sectional Studies
Forced Expiratory Volume
Middle Aged
Practice Guidelines as Topic / standards
Reference Values
Risk Factors
Sex Factors
Smoking / adverse effects
Spirometry* / statistics & numerical data
Sweden / epidemiology
Vital Capacity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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