Document Detail

Prevalence of airflow obstruction in smokers and never-smokers in Switzerland.
MedLine Citation:
PMID:  20413537     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to measure age-specific prevalence of airflow obstruction in Switzerland in smokers and never-smokers using pulmonary function tests and respiratory symptoms from 6,126 subjects participating in the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults. The lower limit of normal of the forced expiratory volume in 1 s/forced vital capacity ratio was used to define airflow obstruction. Severity of airflow obstruction was graded according to the recommendations of the Global Initiative for Chronic Obstructive Lung Disease. Prevalence of airflow obstruction ranged from 2.5% in subjects aged 30-39 yrs to 8.0% in those aged ≥ 70 yrs. In multivariate analysis, age (OR 2.8, ≥ 70 yrs versus 30-39 yrs), smoking (OR 1.8) and asthma (OR 6.7) were associated with airflow obstruction. Never-smokers constituted 29.3% of subjects with airflow obstruction. Never-smokers with airflow obstruction were younger, more likely to be male and reported asthma more frequently than obstructive smokers. Obstructive smokers and never-smokers had similar level of symptoms and quality of life impairment. The prevalence of airflow obstruction in Switzerland is similar to other developed countries. Never-smokers account for a third of the prevalence, which is higher proportion than elsewhere. Airflow obstruction in never-smokers deserves attention because of its frequency and its similar health impact to that in smokers.
P-O Bridevaux; N M Probst-Hensch; C Schindler; I Curjuric; D Felber Dietrich; O Braendli; M Brutsche; L Burdet; M Frey; M W Gerbase; U Ackermann-Liebrich; M Pons; J-M Tschopp; T Rochat; E W Russi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-22
Journal Detail:
Title:  The European respiratory journal     Volume:  36     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-01     Completed Date:  2011-03-30     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1259-69     Citation Subset:  IM    
Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva,
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MeSH Terms
Age Factors
Airway Obstruction / epidemiology*,  physiopathology
Asthma / epidemiology,  physiopathology
Cohort Studies
Middle Aged
Quality of Life
Respiratory Function Tests
Risk Factors
Severity of Illness Index
Sex Factors
Smoking / epidemiology*,  physiopathology
Switzerland / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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