| Prevalence of vitamin D deficiency in chronic liver disease. | |
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MedLine Citation:
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PMID: 19960254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin D deficiency has been associated with cholestatic liver disease such as primary biliary cirrhosis. Some studies have suggested that cirrhosis can predispose patients to development of osteoporosis because of altered calcium and vitamin D homeostasis. The aim of this study was to determine the prevalence of vitamin D deficiency in patients with chronic liver disease. METHODS: One hundred and eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-related cirrhosis) attending the University of Tennessee Hepatology Clinic had their 25-hydroxyvitamin D level measured. Severity of vitamin D deficiency was graded as mild (20-32 ng/ml), moderate (7-19 ng/ml) or severe (<7 ng/ml), normal being >32 ng/ml. RESULTS: Of patients, 109/118 (92.4%) had some degree of vitamin D deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) had mild, 48.8% (21/43) had moderate, and 30.2% (13/43) had severe vitamin D deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) had mild, 52.6% (30/57) had moderate, and 14% (8/57) had severe vitamin D deficiency. In the nonhepatitis C-related cirrhosis group, 38.9% (7/18) had mild, 27.8% (5/18) had moderate, and 27.8% (5/18) had severe vitamin D deficiency. Severe vitamin D deficiency (<7 ng/ml) was more common among patients with cirrhosis compared with noncirrhotics (29.5% versus 14.1%, P value=0.05). Female gender, African American race, and cirrhosis were independent predictors of severe vitamin D deficiency in chronic liver disease. CONCLUSION: Vitamin D deficiency is universal (92%) among patients with chronic liver disease, and at least one-third of them suffer from severe vitamin D deficiency. African American females are at highest risk of vitamin D deficiency. |
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Authors:
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J Arteh; S Narra; S Nair |
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Publication Detail:
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Type: Journal Article Date: 2009-12-04 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 55 ISSN: 1573-2568 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2624-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans Aged Biological Markers / blood Chi-Square Distribution Female Hepatitis C, Chronic / complications, diagnosis, epidemiology* Humans Liver Cirrhosis / diagnosis, epidemiology*, etiology, virology Logistic Models Male Middle Aged Odds Ratio Prevalence Risk Assessment Risk Factors Severity of Illness Index Sex Factors Vitamin D / analogs & derivatives, blood Vitamin D Deficiency / diagnosis, epidemiology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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