Document Detail

Prevalence of vitamin D deficiency in chronic liver disease.
MedLine Citation:
PMID:  19960254     Owner:  NLM     Status:  MEDLINE    
Vitamin D deficiency has been associated with cholestatic liver disease such as primary biliary cirrhosis. Some studies have suggested that cirrhosis can predispose patients to development of osteoporosis because of altered calcium and vitamin D homeostasis. The aim of this study was to determine the prevalence of vitamin D deficiency in patients with chronic liver disease. METHODS: One hundred and eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-related cirrhosis) attending the University of Tennessee Hepatology Clinic had their 25-hydroxyvitamin D level measured. Severity of vitamin D deficiency was graded as mild (20-32 ng/ml), moderate (7-19 ng/ml) or severe (<7 ng/ml), normal being >32 ng/ml. RESULTS: Of patients, 109/118 (92.4%) had some degree of vitamin D deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) had mild, 48.8% (21/43) had moderate, and 30.2% (13/43) had severe vitamin D deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) had mild, 52.6% (30/57) had moderate, and 14% (8/57) had severe vitamin D deficiency. In the nonhepatitis C-related cirrhosis group, 38.9% (7/18) had mild, 27.8% (5/18) had moderate, and 27.8% (5/18) had severe vitamin D deficiency. Severe vitamin D deficiency (<7 ng/ml) was more common among patients with cirrhosis compared with noncirrhotics (29.5% versus 14.1%, P value=0.05). Female gender, African American race, and cirrhosis were independent predictors of severe vitamin D deficiency in chronic liver disease. CONCLUSION: Vitamin D deficiency is universal (92%) among patients with chronic liver disease, and at least one-third of them suffer from severe vitamin D deficiency. African American females are at highest risk of vitamin D deficiency.
J Arteh; S Narra; S Nair
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Publication Detail:
Type:  Journal Article     Date:  2009-12-04
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2624-8     Citation Subset:  AIM; IM    
Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
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MeSH Terms
African Americans
Biological Markers / blood
Chi-Square Distribution
Hepatitis C, Chronic / complications,  diagnosis,  epidemiology*
Liver Cirrhosis / diagnosis,  epidemiology*,  etiology,  virology
Logistic Models
Middle Aged
Odds Ratio
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Vitamin D / analogs & derivatives,  blood
Vitamin D Deficiency / diagnosis,  epidemiology*
Young Adult
Reg. No./Substance:
0/Biological Markers; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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