Document Detail


Prevalence of UGT1A1 gene polymorphism in patients with hemolytic anemia in southern Brazil.
MedLine Citation:
PMID:  21275655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the work was to determine the variation of UGT1A1 genotypes in patients with hemolytic anemia in the southern Brazil. Three hundred twenty-three patients with hemolytic anemia were genotyped for UGT1A1 along with 232 controls. Allelic and genotypic distribution did not differ among studied groups. The TA7/TA7 genotype presented a frequency that ranged from 3.2% to 18.0% (nonsignificant). Alleles TA5 and TA8 were also found in the sample, even though southern Brazil is a major Caucasoid region. Genotype prevalence was very similar to those of African origins, reflecting the diversity of ethnic origins and the high degree of admixture in southern Brazil. Further studies should be conducted to correlate the modulating role of UGT1A1 polymorphism with the clinical conditions of each patient with hemolytic anemia.
Authors:
Laura Alencastro de Azevedo; Ana Paula Santin; Sandrine Comparsi Wagner; Carina da Fontoura Zaleski; Hugo Bock; Maria Luiza Saraiva-Pereira; Simone Martins de Castro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetic testing and molecular biomarkers     Volume:  15     ISSN:  1945-0257     ISO Abbreviation:  Genet Test Mol Biomarkers     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-07-19     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  101494210     Medline TA:  Genet Test Mol Biomarkers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Hemolytic / epidemiology,  genetics*
Brazil
Gene Frequency
Genotype
Glucuronosyltransferase / genetics*
Humans
Polymorphism, Genetic*
Prevalence
Chemical
Reg. No./Substance:
EC 2.4.1.-/UGT1A1 enzyme; EC 2.4.1.17/Glucuronosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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