| Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure. | |
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MedLine Citation:
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PMID: 22231242 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Heart failure (HF) represents the final stage of chronic chagasic cardiomyopathy (CChC). The diagnosis of CChC is based on the demonstration of anti-Trypanosoma cruzi antibodies (aTcAg) and clinical and epidemiological data. In Venezuela, there are no data about the prevalence of chagasic HF. The aim of this study was to determine the epidemiological, clinical, and inflammatory risk factors associated with seronegative or seropositive HF patients. METHODS: We performed a cross-sectional study in the Venezuelan central-west states among a healthy rural population and in patients admitted to the emergency room with uncompensated HF. RESULTS: The seroprevalence rates of Trypanosoma cruzi antibodies were 11.2% and 40.1% in the healthy population and in HF patients, respectively. Seropositivity in healthy individuals was associated with age, knowledge on triatomine vectors, and having seen wild reservoirs in the house; in HF patients, with contact with the vector and previous clinical diagnosis of Chagas' disease; and in both groups taken together, with age, knowledge on triatomines, and HF. Seropositive patients had prolonged QRS, decreased ejection fraction, and high serum magnesium, all significant as compared with HF seronegative cases. Left atrium enlargement and ventricular hypertrophy were most frequently observed in HF seronegative patients. CRP, IL6, ILβ1, IL2, and FNTα were elevated in 94.5%, 48%, 17.8%, 13.7%, and 6.9% of HF patients, respectively, but only IL2 levels were associated with chagasic HF. CONCLUSIONS: There is a high prevalence of aTcAg in HF patients from the central-west region of Venezuela, and their epidemiological, clinical, and inflammatory features are discreetly different as compared with those of seronegative cases. |
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Authors:
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Iván Bravo Tobar; Freddy Parra; Carlota Nello Pérez; Claudina Rodríguez-Bonfante; Franco Useche; Rafael Bonfante-Cabarcas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista da Sociedade Brasileira de Medicina Tropical Volume: 44 ISSN: 1678-9849 ISO Abbreviation: Rev. Soc. Bras. Med. Trop. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507456 Medline TA: Rev Soc Bras Med Trop Country: Brazil |
Other Details:
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Languages: eng Pagination: 691-6 Citation Subset: IM |
Affiliation:
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Unidade de Bioquímica, Decanato de Ciencias de la Salud, Universidade Centro-Occidental Lisandro Alvarado Barquisimeto, Venezuela. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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