| The prevalence of thyrotoxicosis-related seizures. | |
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MedLine Citation:
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PMID: 20718679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Central nervous system dysfunction, such as hyperexcitation, irritability, and disturbance of consciousness, may occur in patients with thyrotoxicosis. There are also a few case reports of seizures attributed to thyrotoxicosis. The objective of the present study was to determine the prevalence of seizures that appeared to be related to the thyrotoxic state in patients with thyrotoxicosis. METHODS: We retrospectively determined the prevalence and clinical features of seizures in 3382 patients with hyperthyroidism. Among patients with seizures, we excluded those with other causes of seizures or a history of epilepsy. We did not exclude two patients in whom later work-up showed an abnormal magnetic resonance imaging, as their seizures resolved after they became euthyroid. RESULTS: Among the 3382 patients with hyperthyroidism, there were seven patients (0.2%) with seizures who met our criteria. Primary generalized tonic-clonic seizures occurred in four patients (57%), complex partial seizures with secondary generalized tonic-clonic seizures occurred in two patients (29%), and one patient had a focal seizure (14%). The initial electroencephalography (EEG) was normal in two patients (29%), had generalized slow activity in four patients (57%), and had diffuse generalized beta activity in one patient (14%). On magnetic resonance imaging, one patient had diffuse brain atrophy, and one had an old basal ganglia infarct. After the patients became euthyroid, the EEG was repeated and was normal in all patients. During follow-up periods ranging from 18 to 24 months, none of the patients had seizures. CONCLUSIONS: Hyperthyroidism is the precipitating cause of seizures in a small percentage of these patients. In these patients, the prognosis is good if they become euthyroid. The prevalence of thyrotoxicosis-related seizures reported here can be used in conjunction with the prevalence of thyrotoxicosis in the population to estimate the prevalence of thyrotoxicosis-related seizures in populations. |
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Authors:
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Tae-Jin Song; Sun-Jung Kim; Gyu Sik Kim; Young-Chul Choi; Won-Joo Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 20 ISSN: 1557-9077 ISO Abbreviation: Thyroid Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
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Languages: eng Pagination: 955-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain Stem Infarctions / diagnosis, epidemiology Child Electroencephalography Female Humans Magnetic Resonance Imaging Male Middle Aged Prevalence Retrospective Studies Seizures / epidemiology*, etiology* Thyrotoxicosis / complications*, epidemiology* Young Adult |
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