| The Prevalence of Thyroid Cancer and Benign Thyroid Disease in Patients With Familial Adenomatous Polyposis May Be Higher Than Previously Recognized. | |
| | |
MedLine Citation:
|
PMID: 22425061 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: Patients with familial adenomatous polyposis (FAP) are at increased risk for colorectal cancer and extracolonic neoplasms. The prevalence of thyroid cancer (TC) and benign thyroid disease in this patient population is unclear, and guidelines for screening for TC in these patients are not well established. The purpose of this study was to report the prevalence of TC and benign thyroid disease in patients with FAP. METHODS: The prospectively maintained Hereditary Colorectal Cancer Family Registry at Memorial Sloan-Kettering Cancer Center was queried to identify patients with FAP and with TC and/or benign thyroid disease. RESULTS: Sixty-six patients with FAP were identified. There were 30 men and 36 women, with a median age of 38.6 years. Four (6.1%) patients had a history of TC. All were women, with a mean age at TC diagnosis of 36.5 years. Three of the 4 TCs were papillary thyroid cancer. Two patients with TC presented with palpable nodules. An additional 6 (9.1%) patients with FAP had a history of benign thyroid disease, including nodules (3), hypothyroidism (2), cysts (2), goiter (1), and thyroiditis (1). Three of 4 patients with TC and all 6 patients with benign thyroid disease had other extracolonic manifestations associated with FAP. CONCLUSIONS: The prevalences of TC (6.1%) and benign thyroid disease (9.1%) are increased in our patients with FAP and are higher than noted in some previous reports. Periodic thyroid ultrasound screening should be considered in patients with FAP to further elucidate the prevalence and for possible early detection of TC and benign thyroid disease in this population. |
| | |
Authors:
|
Emily Steinhagen; José G Guillem; Gerard Chang; Erin E Salo-Mullen; Jinru Shia; Stephanie Fish; Zsofia K Stadler; Arnold J Markowitz |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-14 |
Journal Detail:
|
Title: Clinical colorectal cancer Volume: - ISSN: 1938-0674 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101120693 Medline TA: Clin Colorectal Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Surgery, Colorectal Service, Memorial Sloan-Kettering Cancer Center, New York, NY. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modafinil for excessive daytime sleepiness in myotonic dystrophy type 1 - The patients' perspective.
Next Document: Transmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laborat...