Document Detail

Prevalence of the ST239 clone of methicillin-resistant Staphylococcus aureus and differences in antimicrobial susceptibilities of ST239 and ST5 clones identified in a Korean hospital.
MedLine Citation:
PMID:  16081886     Owner:  NLM     Status:  MEDLINE    
A total of 188 nonduplicate methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained between 2001 and 2004 in a university hospital in Daegu, Korea, were analyzed for their clonal types by molecular typing techniques, including multilocus sequence typing, spaA typing, staphylococcal chromosomal cassette mec (SCCmec) typing, and pulsed-field gel electrophoresis (PFGE). They were examined for their antimicrobial susceptibilities. The majority (87%) of MRSA isolates belonged to sequence type 239 (ST239; n = 100; 53%) and ST5 (n = 63, 34%) on the basis of sequence typing. MRSA isolates belonging to ST239 were genotypically homogeneous, while those belonging to ST5 showed variations in spaA type, SCCmec type, and PFGE patterns. The rates of resistance of the MRSA isolates belonging to ST239 to trimethoprim, sulfamethoxazole, tobramycin, gentamicin, erythromycin, and tetracycline were significantly higher than those of the isolates belonging to ST5 (P < 0.05). This study demonstrated that the ST239 clone, while rarely detected in Korea, was prevalent and that the antimicrobial susceptibility of the ST239 clone was significantly different from that of the ST5 clone.
Hwa Yun Cha; Dong Chan Moon; Chul Hee Choi; Jae Young Oh; Young Sook Jeong; Yoo Chul Lee; Sung Yong Seol; Dong Taek Cho; Hyun-Ha Chang; Shin-Woo Kim; Je Chul Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  43     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-05     Completed Date:  2005-09-15     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3610-4     Citation Subset:  IM    
Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu 700-422, Korea.
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MeSH Terms
Methicillin Resistance*
Microbial Sensitivity Tests
Staphylococcus aureus / classification,  drug effects*,  genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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