Document Detail

The Prevalence and Risk Factors of Premature Thelarche and Pubarche in 4-8 Years Old Girls.
MedLine Citation:
PMID:  21854448     Owner:  NLM     Status:  Publisher    
Objective:  To assess the prevalence of premature thelarche and pubarche in healthy 4-8 year-old girls and to investigate factors associated with early pubertal development. Method:  Eight hundred and twenty girls were examined by two pediatric endocrinologists to determine Tanner staging. The effects of body mass index, gestational age, intrauterine growth status, age at the first tooth eruption, socio-economical status, maternal age of menarche, and consumption of certain food items on early pubertal development were analyzed through parametric and nonparametric tests. Results:  The prevalence of premature thelarche and of premature pubarche was 8.9% and 4.3% respectively. We found a strong association between the prevalence of premature thelarche and BMI SDS. There were more girls with BMI SDS values above 1 in the premature thelarche group (56.1%) than among the remaining subjects (22.9%). Premature thelarche was not significantly associated with intrauterine growth, premature birth, socioeconomic status, age of first tooth eruption, or maternal age of menarche. Similarly, the amount of milk, eggs, chicken, or fish consumed was not associated with premature thelarche. None of the investigated factors were associated with premature pubarche. Conclusion:  Occurrence of PT is strongly associated with BMI SDS. Studies investigating secular trends in pubertal development must consider a secular change in BMI.
Zeynep Atay; Serap Turan; Tulay Guran; Andrzej Furman; Abdullah Bereket
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-20
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Marmara University, School of Medicine, Department of Pediatric Endocrinology, Istanbul, Turkey Bogazici University, Institute of Environmental Sciences, Istanbul, Turkey.
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