| Prevalence of resistant hypertension in the United States, 2003-2008. | |
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MedLine Citation:
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PMID: 21502568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of resistant hypertension is unknown. Much previous knowledge comes from referral populations or clinical trial participants. Using data from the National Health and Nutrition Examination Survey from 2003 through 2008, nonpregnant adults with hypertension were classified as resistant if their blood pressure was ≥140/90 mm Hg and they reported using antihypertensive medications from 3 different drug classes or drugs from ≥4 antihypertensive drug classes regardless of blood pressure. Among US adults with hypertension, 8.9% (SE: 0.6%) met criteria for resistant hypertension. This represented 12.8% (SE: 0.9%) of the antihypertensive drug-treated population. Of all drug-treated adults whose hypertension was uncontrolled, 72.4% (SE: 1.6%) were taking drugs from <3 classes. Compared with those with controlled hypertension using 1 to 3 medication classes, adults with resistant hypertension were more likely to be older, to be non-Hispanic black, and to have higher body mass index (all P<0.001). They were more likely to have albuminuria, reduced renal function, and self-reported medical histories of coronary heart disease, heart failure, stroke, and diabetes mellitus (P<0.001). Most (85.6% [SE: 2.4%]) individuals with resistant hypertension used a diuretic. Of this group, 64.4% (SE: 3.2%) used the relatively weak thiazide diuretic hydrochlorothiazide. Although not rare, resistant hypertension is currently found in only a modest proportion of the hypertensive population. Among those classified here as resistant, inadequate diuretic therapy may be a modifiable therapeutic target. Cardiovascular diseases, diabetes mellitus, obesity, and renal dysfunction were all common in this population. |
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Authors:
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Stephen D Persell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2011-04-18 |
Journal Detail:
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Title: Hypertension Volume: 57 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-19 Completed Date: 2011-07-22 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1076-80 Citation Subset: IM |
Affiliation:
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Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, 750 N Lake Shore Dr, 10th Floor, Chicago, IL 60611, USA. spersell@nmff.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / classification, therapeutic use* Blood Pressure / drug effects* Cardiovascular Diseases / physiopathology Drug Resistance Drug Therapy / methods, statistics & numerical data Humans Hypertension / drug therapy*, epidemiology, physiopathology* Nutrition Surveys / statistics & numerical data Prevalence Risk Assessment Risk Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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1K08HS015647-01/HS/AHRQ HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
Comment In:
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Hypertension. 2011 Oct;58(4):e23; author reply e24-5
[PMID:
21825223
]
Hypertension. 2011 Jun;57(6):1045-6 [PMID: 21502566 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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