| Prevalence of Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis: Correlation with Physiological Parameters. | |
| | |
MedLine Citation:
|
PMID: 21660584 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this study was to prospectively evaluate the prevalence of pulmonary hypertension (PH) in patients with idiopathic pulmonary fibrosis (IPF). One hundred thirty-nine patients (101 male, mean age = 68.6 ± 9 years), with confirmed IPF and who were admitted to eight Pulmonary Departments in Greece between November 2005 and December 2006 were included in the study. Pulmonary artery systolic pressure (PASP) was estimated by echocardiography, and PH was defined as PASP > 36 mmHg. We compared demographics, pulmonary function tests, NYHA functional status, 6-min walk distance (6MWD), B-type natriuretic peptide (BNP), PaO(2), and P(A-a)O(2) at rest data between patients with PH and without PH (PASP ≤ 36 mmHg). Increased estimated right ventricular systolic pressure was present in 55% of patients (mean PASP = 47.1 ± 11.2 mmHg vs. 30.3 ± 3.8 mmHg, respectively). Patients with PH had a lower but not statistically significant DL(CO) (47.1 ± 18.8 vs. 52.5 ± 20.1), lower PaO(2) at rest (64.6 ± 12.2 vs. 71.1 ± 11.3, P = 0.004), and lower mean 6MWD (282 ± 118 vs. 338 ± 91, P = 0.007). Significant differences were also observed in the NYHA functional status between the two groups (P = 0.02). Statistically significant correlations were observed between PASP and PaO(2) at rest (r = -0.331, P = 0.00), P(A-a)O(2) at rest (r = 0.494, P = 0.00)(,) 6MWD (r = -0.264, P = 0.01), SpO(2) at rest (r = -0.293, P = 0.00), SpO(2) at the end of exercise (r = -0.364, P = 0.00), and also BNP values (r = 0.319, P = 0.01). Moreover, PaO(2) (P = 0.02), P(A-a)O(2) (P = 0.005), and SpO(2) at the end of exercise (P = 0.023) were independent predictors of the presence of estimated PH. Using Doppler echocardiography as a screening tool for the estimation of PH, we found that PH is common in patients with IPF. Gas exchange parameters at rest and exercise desaturation might indicate underlying PH in IPF. |
| | |
Authors:
|
D Papakosta; G Pitsiou; Z Daniil; M Dimadi; E Stagaki; A Rapti; K Antoniou; A Tzouvelekis; T Kontakiotis; S Tryfon; V Polychronopoulos; D Bouros |
Related Documents
:
|
1960364 - The interrelationship between physical exercise, muscle strength and body adiposity in ... 14625204 - Excess body fat in men decreases plasma fatty acid availability and oxidation during en... 11641344 - Influence of aerobic fitness and body fatness on tolerance to uncompensable heat stress. 21205384 - Effects of soya isoflavones and exercise on body composition and clinical risk factors ... 8321104 - Decreased salivary immunoglobulins after intense interval exercise before and after tra... 1735264 - The effects of verapamil on training in patients with ischemic heart disease. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-11 |
Journal Detail:
|
Title: Lung Volume: - ISSN: 1432-1750 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7701875 Medline TA: Lung Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pneumonology, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Exochi, 57010, Thessaloniki, Greece, dpapakos@med.auth.gr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic Influences on Pulmonary Function: A Large Sample Twin Study.
Next Document: Surface modification of Ti-6Al-4 V alloy for biomineralization and specific biological response: pa...