| The Prevalence and Predictors of Airway Hyper-Responsiveness in Sarcoidosis. | |
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MedLine Citation:
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PMID: 22296033 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SUMMARY AT A GLANCE: We found a higher prevalence of airway hyper-responsiveness (AHR) in patients with sarcoidosis using direct (histamine) challenge than indirect (hypertonic saline) challenge, and AHR was inversely associated with baseline % predicted FEV(1) . This suggests that AHR in sarcoidosis reflects the consequences of airway remodelling following inflammation. ABSTRACT: Background and objective: Obstructive airflow limitation is the most common physiological impairment in sarcoidosis. This study determined the prevalence of airway hyper-responsiveness (AHR) in sarcoidosis, the correlation between responses to direct (using histamine) and indirect (using hypertonic saline) bronchial challenge, and the clinical, physiological and radiological predictors of AHR. Methods: Subjects with sarcoidosis and a baseline forced expiratory volume in one second (FEV(1) ) >35% predicted underwent hypertonic and histamine challenge, lung function testing and HRCT of the chest. AHR was defined as a 15% fall in FEV(1) to hypertonic saline, and a 20% fall in FEV(1) to histamine. Results: The 52 subjects had well preserved lung function (FEV(1 ) = 2.8L ± 0.7, 87% predicted). AHR was detected in 5/47 (11%) to hypertonic saline and 19/43 (44%) to histamine challenge. On univariate analysis, response to histamine challenge was predicted by conglomerate fibrosis (p = 0.02) and reticular pattern (p = 0.03) on HRCT. The baseline % predicted FEV(1) was significantly inversely associated with AHR on univariate (p = 0.004), and multivariate analysis (p = 0.01) when adjusted by HRCT patterns. Conclusions: The higher prevalence of AHR using histamine challenge than hypertonic saline challenge, and the association with baseline % predicted FEV(1) , suggests that the AHR in sarcoidosis may reflect the consequences of airway remodelling following inflammation. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
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Authors:
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Lisa M Young; Nichola Good; David Milne; Irene Zeng; John Kolbe; Margaret L Wilsher |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
Affiliation:
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Green Lane Respiratory Services and Department of Radiology, Auckland District Health Board, and Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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