Document Detail


The prevalence and predictors of active brown adipose tissue in Chinese adults.
MedLine Citation:
PMID:  24288355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in the regulation of energy homeostasis. However, nearly every study has been carried out in patients undergoing scanning for cancer surveillance (CS), whose metabolism and BAT activity may not reflect those of healthy individuals. The objective of this study was to investigate the prevalence and predictors of active BAT in Chinese adults, particularly in healthy individuals.
DESIGN: A total of 31,088 consecutive subjects aged ≥18 years who had undergone positron emission tomography/computed tomography (PET/CT) scanning of BAT were evaluated in this study.
METHODS: We measured BAT activity via (18)F-fluorodeoxyglucose PET/CT in subjects who had undergone scanning for either a routine medical checkup (MC) or CS in Shanghai. Then, we investigated the predictors of active BAT, particularly in healthy individuals.
RESULTS: In both groups, the prevalence of BAT was higher in women than in men. Using a multivariate logistic analysis, we found age, sex, BMI, and high thyroid glucose uptake to be significant predictors of BAT activity in the MC group. Similarly, we found age, sex, and BMI to be significant predictors of BAT activity, but not thyroid high glucose uptake, in the CS group.
CONCLUSIONS: In Chinese adults, BAT activity inversely correlates with BMI and thyroid high glucose uptake, which reinforces the central role of brown fat in adult metabolism and provides clues to a potential means for treating the metabolic syndrome.
Authors:
Zhaoyun Zhang; Aaron M Cypess; Qing Miao; Hongying Ye; Chong Wee Liew; Qiongyue Zhang; Ruidan Xue; Shuo Zhang; Chuantao Zuo; Zhensheng Xu; Qiqun Tang; Renming Hu; Yihui Guan; Yiming Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2014-02-04
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  170     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-02-05     Completed Date:  2014-03-31     Revised Date:  2014-08-14    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  359-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / metabolism*
Adolescent
Adult
Asian Continental Ancestry Group
Body Mass Index
China / epidemiology
Female
Fluorodeoxyglucose F18 / diagnostic use
Glucose / metabolism
Humans
Male
Positron-Emission Tomography
Prevalence
Retrospective Studies
Thyroid Gland / metabolism
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
R00 DK090210/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0Z5B2CJX4D/Fluorodeoxyglucose F18; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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