Document Detail


Prevalence of the NKG2D Thr72Ala polymorphism in patients with cervical carcinoma.
MedLine Citation:
PMID:  22480139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The natural killer group 2, member D (NKG2D) receptor is mainly situated on the surface of NK and CD8(+) αβ T cells that are involved in the defense against viral agents and in cancer immunosurveillance. The G>A transition (Thr72Ala) (rs2255336) located in the NKG2D region encoding the transmembrane part of this receptor has been associated with decreased functionality of NK and T cells.
METHODS: Using polymerase chain reaction-restriction fragment length polymorphisms, we examined the NKG2D Thr72Ala polymorphism in patients with cervical cancer (n=353) and controls (n=366) in a Polish population.
RESULTS: We observed an increased frequency of Thr/Thr or/and Thr/Ala genotypes in controls compared with all patients with cervical cancer; however, these differences were not significant. We found a significantly increased frequency of the NKG2D 72Thr allele in controls than in all patients (odds ratio [OR]=0.7410 [95% confidence intervals (CI)=0.5683-0.9662, p=0.0265]). Moreover, stratification of patients based on cancer stage showed a significant increase in the Thr/Thr genotype frequency (OR=0.3086 [95% CI=0.09097-1.047, p=0.0461]), as well as in the Thr/Thr and Thr/Ala genotype frequency (OR=0.4504 [95% CI=0.2891-0.7018, p=0.0003]), in controls compared with patients with cervical cancer in stages III and IV. The frequency of the NKG2D 72Thr allele was also significantly increased in controls as compared with patients in stage III and IV cancer (OR=0.4699 [95% CI=0.3170-0.6967, p=0.0001]).
CONCLUSION: Our studies may suggest that the women with cervical cancer bearing the NKG2D 72Thr gene variant might be protected against progression to advanced stages of this cancer.
Authors:
Andrzej Roszak; Margarita Lianeri; Paweł P Jagodziński
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-05
Journal Detail:
Title:  Genetic testing and molecular biomarkers     Volume:  16     ISSN:  1945-0257     ISO Abbreviation:  Genet Test Mol Biomarkers     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-29     Completed Date:  2013-01-14     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  101494210     Medline TA:  Genet Test Mol Biomarkers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  841-5     Citation Subset:  IM    
Affiliation:
Department of Radiotherapy and Gynecological Oncology, Greater Poland Cancer Center, Poznań, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alanine / genetics*
Base Sequence
Case-Control Studies
DNA Primers
Female
Humans
Middle Aged
NK Cell Lectin-Like Receptor Subfamily K / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Threonine / genetics*
Uterine Cervical Neoplasms / genetics*
Chemical
Reg. No./Substance:
0/DNA Primers; 0/NK Cell Lectin-Like Receptor Subfamily K; 56-41-7/Alanine; 72-19-5/Threonine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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