Document Detail

Prevalence of Metabolic Syndrome in Spanish Patients with Schizophrenia and Overweight. The CRESSOB Study.
MedLine Citation:
PMID:  24504989     Owner:  NLM     Status:  In-Data-Review    
Introduction: Metabolic syndrome (MS) (visceral obesity, dyslipidemia, hyperglycemia, and hypertension), has become one of the major public-health challenges worldwide. Patients with schizophrenia are more likely to suffer from MS than the general population. Objective: The primary aim of this study was to analyze the prevalence of MS in Spanish patients with schizophrenia and overweight and to compare the best method to calculate the MS prevalence in this population. A secondary aim of the CRESSOB study was to determine whether the presence of the metabolic syndrome (MS) is associated or not with clinical remission of schizophrenia. Methods: The Control of Metabolic and Cardiovascular Risk in Patients with Schizophrenia and Overweight (CRESSOB) study is a 12-month, prospective, naturalistic study including 110 community mental health clinics selected at random. Each site enrolled four consecutive patients with a diagnosis of schizophrenia, according to DSM-IV TR criteria, and who were overweight (Body Mass Index (BMI) >25 kg/m2). To assess the prevalence of MS we analyzed the baseline results of the CRESSOB study. The National Cholesterol Education Program (NCEP-ATP III), the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) definitions were used to establish the presence of MS. The Positive and Negative Syndrome Scale (PANSS) was used to determine the percentage of patients in remission. Psychosocial functioning was measured by the Global Assessment of Functioning (GAF) scale. Results: A total of 391 patients were enrolled in the study (mean age 40.5 years, 63.8% men). 75.9% of the patients did not meet criteria for remission, using the selected PANSS items. The mean GAF score was 52.7 (Standard Deviation (SD) 15.4). Overall, 59.0% of males and 58.3% of females fulfilled the NCEP-ATP III criteria, 71.1% of males and 65.8% of females fulfilled the IDF criteria and 70.1% of males and 65.1% of females fulfilled the AHA/ NHLBI criteria. The patients who fulfilled remission criteria were younger, had a lower BMI, and a higher GAF score. Conclusions: MS is highly prevalent in Spanish patients with schizophrenia who are overweight. Given that metabolic syndrome is an important risk factor for cardiovascular disease, these patients should receive appropriate clinical monitoring for this syndrome.
Luis Gutiérrez-Rojas; José R Azanza; Miquel Bernardo; Luis Rojo; Francisco Mesa; José M Martínez-Ortega
Related Documents :
1242869 - Electrophysiologic effects of tolamolol on atrioventricular conduction in man.
1541139 - Bradyarrhythmias incident to thrombolysis for acute inferior wall infarction. a caveat.
24793469 - Is there any relation between cervical cord plaques and discopathy in patients with mul...
24250159 - Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality...
1008969 - Electrophysiological effects of mexiletine in man.
8609349 - Congenitally corrected transposition of the great arteries in the adult: functional sta...
9168779 - Outward k+ current densities and kv1.5 expression are reduced in chronic human atrial f...
21996409 - Beta-blocker prevents sudden cardiac death in patients with hemodialysis.
25164919 - Development of persistent headache following stroke: a 3-year follow-up.
Publication Detail:
Type:  Journal Article     Date:  2014-01-01
Journal Detail:
Title:  Actas españolas de psiquiatría     Volume:  42     ISSN:  1578-2735     ISO Abbreviation:  Actas Esp Psiquiatr     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886502     Medline TA:  Actas Esp Psiquiatr     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Validation of the Spanish version of the Cardiff Anomalous Perceptions Scale in the general populati...
Next Document:  Is two weeks the optimum duration criterion for major depression?