Document Detail

Prevalence of MLR blocking antibodies before and after immunotherapy.
MedLine Citation:
PMID:  10813539     Owner:  NLM     Status:  MEDLINE    
Immunologically specific blocking factors (BF) are believed to play a protective role in the maintenance of pregnancy. We compared the levels of BF in normal pregnant women and in patients with recurrent spontaneous abortion (RSA) and observed that the two groups differ significantly from one another. MLC inhibitory activity was present throughout normal pregnancy and was found to be specific to the husband's HLA antigens. Immunotherapy was performed in 28 recurrent aborters using husband's lymphocytes, after which levels of blocking antibodies increased in 23 patients. The difference in the label of MLR BF in the preimmunotherapy and postimmunotherapy groups was statistically significant and was associated with successful pregnancy outcome in 82.15% of cases. The appearance of the MLR BF and its continuation in a successful pregnancy might represent an appropriate immune state that may be playing an important role in maintenance of pregnancy.
S Agrawal; M K Pandey; A Pandey
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hematotherapy & stem cell research     Volume:  9     ISSN:  1525-8165     ISO Abbreviation:  J. Hematother. Stem Cell Res.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-08-21     Completed Date:  2000-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892915     Medline TA:  J Hematother Stem Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
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MeSH Terms
Abortion, Habitual / immunology,  therapy*
Antibodies, Blocking / biosynthesis,  blood,  therapeutic use*
Immunotherapy / methods*
Lymphocyte Culture Test, Mixed*
Lymphocytes / immunology
Pregnancy Outcome
Pregnancy Trimesters / immunology
Reg. No./Substance:
0/Antibodies, Blocking

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