| The Prevalence of Long Spinal Cord Lesions and Anti-Aquaporin 4 Antibodies in Neuromyelitis Optica Patients in Taiwan. | |
| | |
MedLine Citation:
|
PMID: 21273778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and Objective: It was the aim of this study to determine the prevalence of anti-aquaporin 4 antibody (anti-AQP4 Ab) and long spinal cord lesions in neuromyelitis optica (NMO) and multiple sclerosis (MS) patients in Taiwan. Asia has a relatively high rate of NMO compared with MS patients. Anti-AQP4 Ab is an important marker for NMO worldwide, but serological data and clinical profiles of NMO patients in Taiwan have not been reported. Methods: This retrospective study compared the clinical symptoms, demographics, spinal cord lesion length and AQP4 Ab status of 34 patients with NMO with 34 patients diagnosed with conventional MS. Results: Our NMO patients were predominantly middle-aged women (median age 45 years), exhibited many relapses (1.0/year) and displayed a higher Expanded Disability Status Scale score (4.75) than conventional MS patients. NMO patients exhibited long spinal cord lesions as detected by MRI. Forty-one percent of the NMO patients had detectable anti-AQP4 Ab. The Expanded Disability Status Scale score was significantly higher in AQP4 Ab- NMO patients. Conclusion: The prevalence of AQP4 Ab in a Taiwanese NMO group was 41%. Long spinal cord lesions and detection of AQP4 Ab helped to differentiate NMO patients from MS patients. Long spinal cord lesions with the anti-AQP4 Ab test may allow for an earlier diagnosis of NMO and improve therapeutic decisions. |
| | |
Authors:
|
Kai-Chen Wang; Ching-Piao Tsai; Chao-Lin Lee; Shao-Yuan Chen; Shyi-Jou Chen |
Related Documents
:
|
16239178 - Single pulse electrical stimulation for identification of structural abnormalities and ... 14641508 - Ictal limb dystonia in temporal lobe epilepsy. an invasive video-eeg finding. 16091308 - Response inhibition and set shifting in patients with frontal lobe epilepsy or temporal... 18486498 - Ictal eeg remains the prominent predictor of seizure-free outcome after temporal lobect... 19915228 - Prognostic value of cardiac troponin i in patients with copd acute exacerbation. 20050958 - The modified anterior line: an alternative linear lesion in perimitral flutter. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-27 |
Journal Detail:
|
Title: European neurology Volume: 65 ISSN: 1421-9913 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: 99-104 Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Graduate Institute of Medical Sciences, National Defense Medical Center, Cheng Hsin General Hospital, Neurological Institute, Taipei-Veterans General Hospital, Taipei, Taiwan, ROC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mild-to-Moderate Neurogenic Pyrexia in Acute Cerebral Infarction.
Next Document: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Combined with Magnetic ...