| Prevalence of IgA antitissue transglutaminase antibodies in children with type 1 diabetes mellitus. | |
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MedLine Citation:
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PMID: 21567461 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The association of celiac disease with type 1 diabetes mellitus is known, but the evolution of celiac disease is most frequently asymptomatic, without any clinical signs. Thus, diagnosis is impossible to make in the absence of serological tests. Our study aimed to determine the prevalence and the efficiency of IgA antitissue transglutaminase antibodies in the screening of celiac disease in children with type 1 diabetes mellitus. Method: During the course of 2008-2009, we performed an analytical clinical study that included the determination of IgA antitissue transglutaminase antibodies in a group of 119 children with type 1 diabetesmellitus. Fifty-seven percent of the subjects were male and 43% were female, with a mean age of 11±4 years. Results: By evaluating IgA antitissue transglutaminase antibodies, we obtained a prevalence of 9.2% in children with type 1 diabetes mellitus, with a sensitivity and specificity of 80 and 82.6%, respectively. Conclusions: There is an increased prevalence of IgA antitissue transglutaminase antibodies, which suggests the need to use this method as an effective first-line test in the screening of celiac disease in children with type 1 diabetes mellitus. J. Clin. Lab. Anal. 25:156-161, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Samaşca Gabriel; Iancu Mihaela; Butnariu Angela; Andreica Mariana; Dejica Doru |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical laboratory analysis Volume: 25 ISSN: 1098-2825 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: United States |
Other Details:
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Languages: eng Pagination: 156-61 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Immunopathology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Gabriel.Samasca@umfcluj.ro. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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