| Prevalence of IgA-antiendomysial antibody in a patient cohort with idiopathic low bone mineral density. | |
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MedLine Citation:
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PMID: 17589950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the frequency of serum IgA-antiendomysial antibody positivity in patients with low bone mineral density and to assess the risk group for screening of celiac disease. METHODS: One hundred and thirty-five patients (14 male, 121 female) with idiopathic low bone mineral density were evaluated. The median age was 57.2 years (24-81). Antiendomysial antibody was determined by the immunofluorescence method using a commercial kit (INOVA Diagnostics Inc., CA, USA), which employs a 5 microm thin cryostat section of monkey esophagus as a substrate. RESULTS: Of the 135 patients evaluated, 13 were found to have positive IgA antiendomysial antibody test (9.6%) response. None of the patients had IgA deficiency. Endoscopic appearance and histological examination were normal in all of these patients. Seropositive patients had significantly lower age (48.9 +/- 4.3 vs 59.2 +/- 6.2, P < 0.05), higher ratio of male gender (61.5% vs 4.9%, P < 0.01) and pre-menopausal status (8.7% vs 1.3%, P < 0.01). Lumbar spine and femoral neck z-scores, but not t-scores were significantly lower in seropositive patients. Seropositive patients had lower serum 25 (OH) vitamin D, calcium and higher serum parathormone levels than seronegative patients. CONCLUSION: The screening of celiac disease in idiopathic osteoporosis should be restricted to patients without classical risk factors (younger, pre-menopausal, male gender) for osteoporosis. Bone mineral density measurements using z-scores should be considered for identifying risk groups for celiac disease. |
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Authors:
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T Karakan; O Ozyemisci-Taskiran; Z Gunendi; F Atalay; C Tuncer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-08-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 2978-82 Citation Subset: IM |
Affiliation:
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Gazi University, Faculty of Medicine, Department of Gastroenterology, Ankara, Turkey. tkarakan@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Autoantibodies / blood* Bone Density / immunology* Bone Diseases, Metabolic / blood, etiology, immunology Calcium / blood Celiac Disease / blood, complications*, immunology Cohort Studies Female Health Surveys Humans Immunoglobulin A / immunology* Male Middle Aged Osteoporosis / blood, etiology, immunology Parathyroid Hormone / blood Prevalence Prospective Studies Reticulin / immunology Risk Factors Sex Factors Vitamin D / analogs & derivatives, blood |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulin A; 0/Parathyroid Hormone; 0/Reticulin; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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