Document Detail

Prevalence of IgA-antiendomysial antibody in a patient cohort with idiopathic low bone mineral density.
MedLine Citation:
PMID:  17589950     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the frequency of serum IgA-antiendomysial antibody positivity in patients with low bone mineral density and to assess the risk group for screening of celiac disease.
METHODS: One hundred and thirty-five patients (14 male, 121 female) with idiopathic low bone mineral density were evaluated. The median age was 57.2 years (24-81). Antiendomysial antibody was determined by the immunofluorescence method using a commercial kit (INOVA Diagnostics Inc., CA, USA), which employs a 5 microm thin cryostat section of monkey esophagus as a substrate.
RESULTS: Of the 135 patients evaluated, 13 were found to have positive IgA antiendomysial antibody test (9.6%) response. None of the patients had IgA deficiency. Endoscopic appearance and histological examination were normal in all of these patients. Seropositive patients had significantly lower age (48.9 +/- 4.3 vs 59.2 +/- 6.2, P < 0.05), higher ratio of male gender (61.5% vs 4.9%, P < 0.01) and pre-menopausal status (8.7% vs 1.3%, P < 0.01). Lumbar spine and femoral neck z-scores, but not t-scores were significantly lower in seropositive patients. Seropositive patients had lower serum 25 (OH) vitamin D, calcium and higher serum parathormone levels than seronegative patients.
CONCLUSION: The screening of celiac disease in idiopathic osteoporosis should be restricted to patients without classical risk factors (younger, pre-menopausal, male gender) for osteoporosis. Bone mineral density measurements using z-scores should be considered for identifying risk groups for celiac disease.
T Karakan; O Ozyemisci-Taskiran; Z Gunendi; F Atalay; C Tuncer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-08-16     Revised Date:  2014-09-25    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2978-82     Citation Subset:  IM    
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MeSH Terms
Age Factors
Aged, 80 and over
Autoantibodies / blood*
Bone Density / immunology*
Bone Diseases, Metabolic / blood,  etiology,  immunology
Calcium / blood
Celiac Disease / blood,  complications*,  immunology
Cohort Studies
Health Surveys
Immunoglobulin A / immunology*
Middle Aged
Osteoporosis / blood,  etiology,  immunology
Parathyroid Hormone / blood
Prospective Studies
Reticulin / immunology
Risk Factors
Sex Factors
Vitamin D / analogs & derivatives,  blood
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin A; 0/Parathyroid Hormone; 0/Reticulin; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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