Document Detail


Prevalence of human papillomavirus genotypes in cervical cancer.
MedLine Citation:
PMID:  22706225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Cervical cancer is the second most common female genital cancer worldwide. There is strong epidemiological and molecular evidence indicating that human papillomavirus (HPV) infection is a necessary event in the development of cervical intraepithelial lesion and subsequent invasive carcinoma. The aim of this study was to investigate the HPV genotype distribution and prevalence in cervical cancer of Thai women.
MATERIALS AND METHODS: One hundred fifty-five cervical cancer specimens were enrolled in this study. The HPV genotypes were determined by means of the combined use of a line probe assay (INNO-LiPA) and DNA chip methods.
RESULTS: Of the overall prevalence of HPV in the study group, 83.2% and 11.6% of the cases had single and multiple genotype infections, respectively. The most prevalent genotypes were HPV 16 (51%), followed by HPV 18 (20%), HPV 52 (10.3%), HPV 58 (5.8%), and HPV 33 (4.5%). All HPV genotypes found in this study could be classified as 13 high-risk HPV, 2 low-risk HPV, and 2 additional types. Of the specimens, 94.8% had at least one high-risk HPV genotype infection.
CONCLUSION: As for the potential benefits of commercially available prophylactic vaccines to prevent HPV infection in Thailand, both vaccines (bivalent and quadrivalent) can protect from HPV-related cervical cancer in only approximately 71%. Therefore, screening programs such as routine Papanicolaou test, cytology, and HPV DNA detection are still essential for cervical cancer prevention. Moreover, future generations of HPV vaccines should also include the other most common genotypes and decrease the severe adverse effects reported at the present time.
Authors:
Teeraporn Chinchai; Jira Chansaenroj; Sukumarn Swangvaree; Pairoj Junyangdikul; Yong Poovorawan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  22     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-29     Completed Date:  2012-11-08     Revised Date:  2012-11-26    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1063-8     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alphapapillomavirus / genetics*
Female
Genotyping Techniques
Humans
Middle Aged
Papillomavirus Infections / complications,  virology*
Thailand / epidemiology
Uterine Cervical Neoplasms / epidemiology,  virology*
Comments/Corrections
Comment In:
Int J Gynecol Cancer. 2012 Oct;22(8):1290   [PMID:  23013729 ]

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