| Prevalence of HLA DQB1*0602 allele in patients with migraine. | |
| | |
MedLine Citation:
|
PMID: 18345414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Studies have shown a high prevalence of migraine among narcoleptic patients. HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine. PURPOSE: Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hypothesize that HLA-DQB1*0602 might be associated to the pathophysiology of migraine. METHOD: We analyzed the presence of HLA DQB1*0602 allele in 50 healthy subjects with no history of migraine, 53 patients with migraine without aura and 52 patients with migraine with aura. RESULTS: There was no difference in the frequency of HLA DQB1*0602 allele when control subjects and all patients were compared. We failed to note any difference in frequencies when comparing migraine patients with and without aura. CONCLUSION: Further studies with different patient populations, with other hypothalamic markers (melatonin, hypocretin) in migraine patients may shed light on to its pathophysiology. |
| | |
Authors:
|
Fernando Morgadinho Santos Coelho; Márcia Pradella-Hallinan; Paulo Corrêa Abud; Mario Predazzoli Neto; Fabio Moreira; Lia Rita Azeredo Bittencourt; Mario Fernandes Pietro Peres; Sérgio Tufik |
Related Documents
:
|
19116034 - Myofascial trigger points in cluster headache patients: a case series. 8857754 - Elevation of cerebral lactate detected by localized 1h-magnetic resonance spectroscopy ... 8880714 - Evaluation of the clinical safety of gadodiamide injection, a new nonionic mri contrast... 7347624 - Cluster headache: severity and temporal profiles of attacks and patient activity prior ... 23584934 - Resistance index in mural arteries of thickened bowel wall: predictive value for crohn ... 15641964 - Salivary gland and temporomandibular joint involvement in rheumatoid arthritis: relatio... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arquivos de neuro-psiquiatria Volume: 65 ISSN: 0004-282X ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2008-03-17 Completed Date: 2008-10-07 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
|
Languages: eng Pagination: 1123-5 Citation Subset: IM |
Affiliation:
|
Psychobiology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil. fernandomorgadinho@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alleles* Case-Control Studies Female Genetic Markers Genetic Predisposition to Disease HLA-DQ Antigens / genetics* Humans Male Membrane Glycoproteins / genetics* Migraine with Aura / genetics* Migraine without Aura / genetics* Polymerase Chain Reaction Prevalence |
| Chemical | |
Reg. No./Substance:
|
0/Genetic Markers; 0/HLA-DQ Antigens; 0/HLA-DQB1 protein, human; 0/Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunoexpression of tumor suppressor genes p53, p21 WAF1/CIP1 and p27 KIP1 in humam astrocystic tumo...
Next Document: Chronic daily headache: stress and impact on the quality of life.