Document Detail

Prevalence of HLA DQB1*0602 allele in patients with migraine.
MedLine Citation:
PMID:  18345414     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies have shown a high prevalence of migraine among narcoleptic patients. HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine. PURPOSE: Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hypothesize that HLA-DQB1*0602 might be associated to the pathophysiology of migraine. METHOD: We analyzed the presence of HLA DQB1*0602 allele in 50 healthy subjects with no history of migraine, 53 patients with migraine without aura and 52 patients with migraine with aura. RESULTS: There was no difference in the frequency of HLA DQB1*0602 allele when control subjects and all patients were compared. We failed to note any difference in frequencies when comparing migraine patients with and without aura. CONCLUSION: Further studies with different patient populations, with other hypothalamic markers (melatonin, hypocretin) in migraine patients may shed light on to its pathophysiology.
Fernando Morgadinho Santos Coelho; Márcia Pradella-Hallinan; Paulo Corrêa Abud; Mario Predazzoli Neto; Fabio Moreira; Lia Rita Azeredo Bittencourt; Mario Fernandes Pietro Peres; Sérgio Tufik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  65     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-10-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1123-5     Citation Subset:  IM    
Psychobiology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
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MeSH Terms
Case-Control Studies
Genetic Markers
Genetic Predisposition to Disease
HLA-DQ Antigens / genetics*
Membrane Glycoproteins / genetics*
Migraine with Aura / genetics*
Migraine without Aura / genetics*
Polymerase Chain Reaction
Reg. No./Substance:
0/Genetic Markers; 0/HLA-DQ Antigens; 0/HLA-DQB1 protein, human; 0/Membrane Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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